Dexpramipexole

Modify Date: 2024-01-02 11:11:29

Dexpramipexole structure	Common Name	Dexpramipexole
	CAS Number	104632-28-2	Molecular Weight	211.331
	Density	1.17±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₁₀H₁₇N₃S	Melting Point	270-272ºC
	MSDS	N/A	Flash Point	N/A

Use of Dexpramipexole

Dexpramipexole(KNS-760704), also known as R-(+)-Pramipexole, is a neuroprotective agent and weak non-ergoline dopamine agonist. IC50 Value:Target: Dopamine ReceptorDexpramipexole has been found to have neuroprotective effects and is being investigated for treatment of amyotrophic lateral sclerosis (ALS). Dexpramipexole reduces mitochondrial reactive oxygen species (ROS) production, inhibits the activation of apoptotic pathways, and increase cell survival in response to a variety of neurotoxins and β-amyloid neurotoxicity. Compared to the S-(-) isomer, Dexpramipexole has much lower dopamine agonist activity.

Name	(6R)-6-N-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine
Synonym	More Synonyms

Description	Dexpramipexole(KNS-760704), also known as R-(+)-Pramipexole, is a neuroprotective agent and weak non-ergoline dopamine agonist. IC50 Value:Target: Dopamine ReceptorDexpramipexole has been found to have neuroprotective effects and is being investigated for treatment of amyotrophic lateral sclerosis (ALS). Dexpramipexole reduces mitochondrial reactive oxygen species (ROS) production, inhibits the activation of apoptotic pathways, and increase cell survival in response to a variety of neurotoxins and β-amyloid neurotoxicity. Compared to the S-(-) isomer, Dexpramipexole has much lower dopamine agonist activity.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease
References	[1]. Rudnicki SA, Berry JD, Ingersoll E, et al. Dexpramipexole effects on functional decline and survival in subjects with amyotrophic lateral sclerosis in a Phase II study: subgroup analysis of demographic and clinical characteristics. Amyotroph Lateral Scler [2]. Alavian KN, Dworetzky SI, Bonanni L, et al. Effects of dexpramipexole on brain mitochondrial conductances and cellular bioenergetic efficiency. Brain Res. 2012 Mar 29;1446:1-11. [3]. Cudkowicz M, Bozik ME, Ingersoll EW, et al. The effects of dexpramipexole (KNS-760704) in individuals with amyotrophic lateral sclerosis. Nat Med. 2011 Nov 20;17(12):1652-6. [4]. Bozik ME, Mather JL, Kramer WG, et al. Safety, tolerability, and pharmacokinetics of KNS-760704 (dexpramipexole) in healthy adult subjects. J Clin Pharmacol. 2011 Aug;51(8):1177-85. [5]. Cheah BC, Kiernan MC. Dexpramipexole, the R(+) enantiomer of pramipexole, for the potential treatment of amyotrophic lateral sclerosis. IDrugs. 2010 Dec;13(12):911-20.

Description

Related Catalog

Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor

Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor

Research Areas >> Neurological Disease

References

[1]. Rudnicki SA, Berry JD, Ingersoll E, et al. Dexpramipexole effects on functional decline and survival in subjects with amyotrophic lateral sclerosis in a Phase II study: subgroup analysis of demographic and clinical characteristics. Amyotroph Lateral Scler

[2]. Alavian KN, Dworetzky SI, Bonanni L, et al. Effects of dexpramipexole on brain mitochondrial conductances and cellular bioenergetic efficiency. Brain Res. 2012 Mar 29;1446:1-11.

[3]. Cudkowicz M, Bozik ME, Ingersoll EW, et al. The effects of dexpramipexole (KNS-760704) in individuals with amyotrophic lateral sclerosis. Nat Med. 2011 Nov 20;17(12):1652-6.

[4]. Bozik ME, Mather JL, Kramer WG, et al. Safety, tolerability, and pharmacokinetics of KNS-760704 (dexpramipexole) in healthy adult subjects. J Clin Pharmacol. 2011 Aug;51(8):1177-85.

[5]. Cheah BC, Kiernan MC. Dexpramipexole, the R(+) enantiomer of pramipexole, for the potential treatment of amyotrophic lateral sclerosis. IDrugs. 2010 Dec;13(12):911-20.

Density	1.17±0.1 g/cm3
Melting Point	270-272ºC
Molecular Formula	C₁₀H₁₇N₃S
Molecular Weight	211.331
PSA	83.52000
LogP	4.38490
Water Solubility	Slightly soluble (1.1 g/L) (25 ºC)

Hazard Codes	Xi
HS Code	2934999090

(R)-(+)-2-amino...

CAS#:1332723-78-0

Dexpramipexole

CAS#:104632-28-2

Literature: WO2013/96816 A1, ; Paragraph 000145-000146 ;

(R)-N-(2-AMINO-...

CAS#:106006-85-3

Dexpramipexole

CAS#:104632-28-2

Literature: Journal of Medicinal Chemistry, , vol. 30, # 3 p. 494 - 498

D-Tartaric acid

CAS#:147-71-7

(±)-Pramipexole

CAS#:104617-86-9

Dexpramipexole

CAS#:104632-28-2

Pramipexole

CAS#:104632-26-0

Literature: WO2010/22140 A1, ; Page/Page column 100-101 ;

(+)-(6R)-2,6-di...

CAS#:106092-11-9

Dexpramipexole

CAS#:104632-28-2

Literature: Journal of Medicinal Chemistry, , vol. 30, # 3 p. 494 - 498

4,5,6,7-TETRAHY...

CAS#:106006-83-1

Dexpramipexole

CAS#:104632-28-2

Literature: Journal of Medicinal Chemistry, , vol. 30, # 3 p. 494 - 498

(±)-Pramipexole

CAS#:104617-86-9

~0%

Dexpramipexole

CAS#:104632-28-2

Pramipexole

CAS#:104632-26-0

Literature: GENERICS [UK] LIMITED Patent: WO2006/3471 A2, 2006 ; Location in patent: Page/Page column 9-11 ;

Precursor 5
CAS#:106006-85-3 (R)-N-(2-AMINO-... CAS#:147-71-7 D-Tartaric acid CAS#:104617-86-9 (±)-Pramipexole CAS#:106092-11-9 (+)-(6R)-2,6-di...
CAS#:106006-83-1 4,5,6,7-TETRAHY...
DownStream 0

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Dexpramipexole

(6R)-2-amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole

(R)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine

(6R)-4,5,6,7-tetrahydro-N6-propylbenzothiazole-2,6-diamine

(R)-Pramipexole Dihydrochloride

Pramipexole [USAN:INN]

(R)-(+)-2-amino-4,5,6,7-tetrahydro-6-(n-propylamino)benzothiazole

(R)-Pramipexole

(R)-(+)-pramipexole

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Dexpramipexole
Price: ￥1318.0/50mg ￥2418.0/100mg ￥558.0/10mg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Dexpramipexole
Price: $Inquiry/250mg $Inquiry/1g $200.0/100mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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Dexpramipexole

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