(R)-普拉克索

• 常用名: (R)-普拉克索
• 英文名: Dexpramipexole
• CAS号: 104632-28-2
• 分子量: 211.331
• 密度: 1.17±0.1 g/cm3
• 沸点: N/A
• 分子式: C₁₀H₁₇N₃S
• 熔点: 270-272ºC
• 闪点: N/A

(R)-普拉克索用途

Dexpramipexole(KNS-760704)也叫R-(+)-Pramipexole,是神经保护剂,是弱的非麦角类多巴胺受体激动剂。

(R)-普拉克索名称

• 中文名: R-普拉克索
• 英文名: (6R)-6-N-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine
• 中文别名: (R)-普拉克索二盐酸化物 | (R)-普拉克索 | 普拉克索杂质E

(R)-普拉克索生物活性

• 描述: Dexpramipexole(KNS-760704)也叫R-(+)-Pramipexole,是神经保护剂,是弱的非麦角类多巴胺受体激动剂。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 多巴胺受体
  信号通路 >> 神经信号通路 >> 多巴胺受体
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Rudnicki SA, Berry JD, Ingersoll E, et al. Dexpramipexole effects on functional decline and survival in subjects with amyotrophic lateral sclerosis in a Phase II study: subgroup analysis of demographic and clinical characteristics. Amyotroph Lateral Scler

  [2]. Alavian KN, Dworetzky SI, Bonanni L, et al. Effects of dexpramipexole on brain mitochondrial conductances and cellular bioenergetic efficiency. Brain Res. 2012 Mar 29;1446:1-11.

  [3]. Cudkowicz M, Bozik ME, Ingersoll EW, et al. The effects of dexpramipexole (KNS-760704) in individuals with amyotrophic lateral sclerosis. Nat Med. 2011 Nov 20;17(12):1652-6.

  [4]. Bozik ME, Mather JL, Kramer WG, et al. Safety, tolerability, and pharmacokinetics of KNS-760704 (dexpramipexole) in healthy adult subjects. J Clin Pharmacol. 2011 Aug;51(8):1177-85.

  [5]. Cheah BC, Kiernan MC. Dexpramipexole, the R(+) enantiomer of pramipexole, for the potential treatment of amyotrophic lateral sclerosis. IDrugs. 2010 Dec;13(12):911-20.

(R)-普拉克索物理化学性质

• 密度: 1.17±0.1 g/cm3
• 熔点: 270-272ºC
• 分子式: C₁₀H₁₇N₃S
• 分子量: 211.331
• PSA: 83.52000
• LogP: 4.38490
• InChIKey: FASDKYOPVNHBLU-SSDOTTSWSA-N
• SMILES: CCCNC1CCc2nc(N)sc2C1
• 储存条件: 室温，干燥，密封
• 水溶解性: Slightly soluble (1.1 g/L) (25 ºC)

(R)-普拉克索安全信息

• 危害码 (欧洲): Xi
• 海关编码: 2934999090

(R)-普拉克索海关

• 海关编码: 2934999090
• 中文概述: 2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
• 申报要素: 品名, 成分含量, 用途
• Summary: 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

(R)-普拉克索英文别名

• Dexpramipexole
• (6R)-2-amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole
• (R)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine
• (6R)-4,5,6,7-tetrahydro-N6-propylbenzothiazole-2,6-diamine
• (R)-Pramipexole Dihydrochloride
• Pramipexole [USAN:INN]
• (R)-(+)-2-amino-4,5,6,7-tetrahydro-6-(n-propylamino)benzothiazole
• (R)-Pramipexole
• (R)-(+)-pramipexole