9-ING-41
Modify Date: 2024-01-22 15:26:56
9-ING-41 structure
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Common Name | 9-ING-41 | ||
|---|---|---|---|---|
| CAS Number | 1034895-42-5 | Molecular Weight | 404.34700 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H13FN2O5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of 9-ING-419-ING-41 is a potent glycogen synthase kinase-3 (GSK-3) inhibitor[1]. 9-ING-41 induces apoptosis and cell cycle arrest at prophase by targeting centrosomes and microtubule-bound GSK-3β. 9-ING-41 has anticancer activity[2]. |
| Name | 3-(5-fluorobenzofuran-3-yl)-4-(5-methyl-5H-[1,3]dioxolo[4,5-f]indol-7-yl)-1H-pyrrole-2,5-dione |
|---|---|
| Synonym | More Synonyms |
| Description | 9-ING-41 is a potent glycogen synthase kinase-3 (GSK-3) inhibitor[1]. 9-ING-41 induces apoptosis and cell cycle arrest at prophase by targeting centrosomes and microtubule-bound GSK-3β. 9-ING-41 has anticancer activity[2]. |
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| Related Catalog | |
| Target |
GSK-3β |
| In Vitro | 9-ING-41 (2, 4 μM; 48 hours) decreases neuroblastoma cell viability induces apoptosis[2]. 9-ING-41 (1, 2 μM; 24 hours) is a potent cell cycle-blocking agent for lymphoma cells[2]. 9-ING-41 (0.1-1 µM) inhibits GSK-3 leading to a decreased expression of the NF-κB target XIAP and significant apoptosis in neuroblastoma cells as shown by PARP cleavage, an apoptosis marker[1]. 9-ING-41 (0.5, 1.0, 1.5, 2.0 μM) inhibits the proliferation rate of all TCL and MCL lines with concentrations as low as 1.0 mM[2]. Cell Viability Assay[2] Cell Line: TCL and MCL lines Concentration: 2, 4 μM Incubation Time: 48 hours Result: Induced apoptosis. Cell Cycle Analysis[2] Cell Line: Lymphoma cells (Jeko, Mino, and OCI-Ly cell lines) Concentration: 1, 2 μM Incubation Time: 24 hours Result: Led to cell cycle arrest in G2/M. Western Blot Analysis[1] Cell Line: SK-N-DZ and SK-N-BE neuroblastoma cells Concentration: 0.1, 1 µM Incubation Time: 48 hours Result: Inhibited GSK-3 leading to a decreased expression of the NF-κB target XIAP. |
| In Vivo | 9-ING-41 (40 mg/kg/every other day; for 17 days) has single-agent antitumor activity in a mouse model of MCL[2]. Animal Model: NSG (NOD.Cg-PrkdcscidIl2rgtm1Wjl/SzJ) mice[2] Dosage: 40 mg/kg Administration: Every other day; for 17 days Result: Had single-agent antitumor activity in a mouse model of MCL. |
| References |
| Molecular Formula | C22H13FN2O5 |
|---|---|
| Molecular Weight | 404.34700 |
| Exact Mass | 404.08100 |
| PSA | 82.70000 |
| LogP | 3.68830 |
| Storage condition | -20°C |
| 9-ING-41 |
| 3-(5-fluorobenzofuran-3-yl)-4-(5-methyl-5H-[1,3]dioxolo[4,5-f]indol-7-yl)pyrrole-2,5-dione |
| 3-(5-fluoro-benzofuran-3-yl)-4-(5-methyl-5H-[1,3]dioxolo[4,5-f]indol-7-yl)-pyrrole-2,5-dione |