Lenalidomide-5-Br

Modify Date: 2024-01-06 18:58:10

Lenalidomide-5-Br Structure
Lenalidomide-5-Br structure
 Common Name Lenalidomide-5-Br
CAS Number 1010100-26-1 Molecular Weight 323.14
Density 1.688±0.06 g/cm3 Boiling Point 587.6±50.0 °C
Molecular Formula C13H11BrN2O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Lenalidomide-5-Br


Lenalidomide-5-Br is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-5-Br can be connected to the ligand for protein by a linker to form PROTAC[1].

 Names

Name Lenalidomide-5-Br
Synonym More Synonyms

 Lenalidomide-5-Br Biological Activity

Description Lenalidomide-5-Br is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-5-Br can be connected to the ligand for protein by a linker to form PROTAC[1].
Related Catalog
Target

Cereblon

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References

[1]. Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery. Comput Struct Biotechnol J. 2019;17:160-176. Published 2019 Jan 25.

[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

 Chemical & Physical Properties

Density 1.688±0.06 g/cm3
Boiling Point 587.6±50.0 °C
Molecular Formula C13H11BrN2O3
Molecular Weight 323.14

 Synonyms

3-(5-bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione
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Chemsrc provides Lenalidomide-5-Br(CAS#:1010100-26-1) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Lenalidomide-5-Br are included as well.>> amp version: Lenalidomide-5-Br

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