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Lenalidomide-5-Br

Names

[ CAS No. ]:
1010100-26-1

[ Name ]:
Lenalidomide-5-Br

[Synonym ]:
3-(5-bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione

Biological Activity

[Description]:

Lenalidomide-5-Br is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-5-Br can be connected to the ligand for protein by a linker to form PROTAC[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> Ligand for E3 Ligase

[Target]

Cereblon


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

[References]

[1]. Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery. Comput Struct Biotechnol J. 2019;17:160-176. Published 2019 Jan 25.

[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

Chemical & Physical Properties

[ Density]:
1.688±0.06 g/cm3

[ Boiling Point ]:
587.6±50.0 °C

[ Molecular Formula ]:
C13H11BrN2O3

[ Molecular Weight ]:
323.14

Related Compounds