Piceatannol

Modify Date: 2024-01-03 18:25:49

Piceatannol structure	Common Name	Piceatannol
	CAS Number	10083-24-6	Molecular Weight	244.243
	Density	1.5±0.1 g/cm3	Boiling Point	507.3±38.0 °C at 760 mmHg
	Molecular Formula	C₁₄H₁₂O₄	Melting Point	223-227ºC
	MSDS	Chinese USA	Flash Point	252.2±21.4 °C

Use of Piceatannol

Piceatannol is a selective inhibitor of protein tyrosine kinase Syk. It could inhibit ICa,L, Ito, IKr, Ca2+ transients and Na+-Ca2+ exchange except IK1. Shows multiple biological activities such as anti-inflammatory, antiproliferative and immunomodulatory effects.In vitro: The treatment of human myeloid cells with piceatannol suppressed TNF-induced DNA binding activity of NF-κB. The effect of piceatannol was not restricted to myeloid cells, as TNF-induced NF-κB activation was also suppressed in lymphocyte and epithelial cells. Piceatannol also inhibited NF-κB activated by H2O2, PMA, LPS, okadaic acid, and ceramide. [1]

Name	Piceatannol
Synonym	More Synonyms

Description	Piceatannol is a selective inhibitor of protein tyrosine kinase Syk. It could inhibit ICa,L, Ito, IKr, Ca2+ transients and Na+-Ca2+ exchange except IK1. Shows multiple biological activities such as anti-inflammatory, antiproliferative and immunomodulatory effects.In vitro: The treatment of human myeloid cells with piceatannol suppressed TNF-induced DNA binding activity of NF-κB. The effect of piceatannol was not restricted to myeloid cells, as TNF-induced NF-κB activation was also suppressed in lymphocyte and epithelial cells. Piceatannol also inhibited NF-κB activated by H2O2, PMA, LPS, okadaic acid, and ceramide. [1]
Related Catalog	Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Syk Research Areas >> Cancer Natural Products >> Phenols
References	[1]. Kazuhiro Ashikawa et al. Piceatannol Inhibits TNF-Induced NF-κB Activation and NF-κB-Mediated Gene Expression Through Suppression of IκBα Kinase and p65 Phosphorylation. J Immunol, 2002 Dec 1, 169(11):6490-7. [2]. Wen-Pin Chen et al. Piceatannol, a derivative of resveratrol, moderately slows INa inactivation and exerts antiarrhythmic action in ischaemia-reperfused rat hearts. Br J Pharmacol.2009 Jun, 157(3), 381-391.

Description

Related Catalog

Signaling Pathways >> Autophagy >> Autophagy

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Syk

Research Areas >> Cancer

Natural Products >> Phenols

References

[1]. Kazuhiro Ashikawa et al. Piceatannol Inhibits TNF-Induced NF-κB Activation and NF-κB-Mediated Gene Expression Through Suppression of IκBα Kinase and p65 Phosphorylation. J Immunol, 2002 Dec 1, 169(11):6490-7.

[2]. Wen-Pin Chen et al. Piceatannol, a derivative of resveratrol, moderately slows INa inactivation and exerts antiarrhythmic action in ischaemia-reperfused rat hearts. Br J Pharmacol.2009 Jun, 157(3), 381-391.

Density	1.5±0.1 g/cm3
Boiling Point	507.3±38.0 °C at 760 mmHg
Melting Point	223-227ºC
Molecular Formula	C₁₄H₁₂O₄
Molecular Weight	244.243
Flash Point	252.2±21.4 °C
Exact Mass	244.073563
PSA	80.92000
LogP	2.69
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.801
Storage condition	2-8°C
Water Solubility	H2O: 0.5 mg/mL

Piceatannol MSDS(Chinese)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases	24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2907299090

HS Code	2907299090
Summary	2907299090 polyphenols; phenol-alcohols。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:5.5%。general tariff:30.0%

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3,3',4'5-Tetrahydroxystilbene

E-Piceatannol

1,2-Benzenediol, 4-[(E)-2-(3,5-dihydroxyphenyl)ethenyl]-

3,3′,4,5′-Tetrahydroxy-trans-stilbene

3,3',4,5'-Tetrahydroxy-trans-stilbene

3,4,3',5'-Tetrahydroxy-trans-stilbene

4-[(E)-2-(3,5-Dihydroxyphenyl)vinyl]benzene-1,2-diol

3,5,3',4'-tetrahydroxystilbene

4-[(E)-2-(3,5-Dihydroxyphenyl)vinyl]-1,2-benzenediol

Piceatannol

4-[(E)-2-(3,5-dihydroxyphenyl)ethenyl]benzene-1,2-diol

MFCD00221715

4-(2-(3,5-Dihydroxyphenyl)vinyl)-1,2-benzenediol

(E)-4-[2-(3,5Dihydroxyphenyl)ethenyl]1,2-benzenediol

(E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol

5-[(E)-2-(3,4-Dihydroxyphenyl)vinyl]benzene-1,3-diol

trans-3,3',4,5'-tetrahydroxystilbene

3,3',4,5'-tetrahydroxystilbene

Piceatannol, (E)-

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China
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China
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China
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China
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Henan Tianfu Chemical Co., Ltd.
China
Product Name: Piceatannol
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Purity: 99.0%
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