10083-24-6

10083-24-6 structure

Name: Piceatannol
Chemical Name: Piceatannol
CAS Number: 10083-24-6
Molecular Formula: C₁₄H₁₂O₄
Molecular Weight: 244.243
Catalog: Natural product Phenols
Create Date: 2018-02-12 08:00:00
Modify Date: 2024-01-03 18:25:49
Piceatannol is a selective inhibitor of protein tyrosine kinase Syk. It could inhibit ICa,L, Ito, IKr, Ca2+ transients and Na+-Ca2+ exchange except IK1. Shows multiple biological activities such as anti-inflammatory, antiproliferative and immunomodulatory effects.In vitro: The treatment of human myeloid cells with piceatannol suppressed TNF-induced DNA binding activity of NF-κB. The effect of piceatannol was not restricted to myeloid cells, as TNF-induced NF-κB activation was also suppressed in lymphocyte and epithelial cells. Piceatannol also inhibited NF-κB activated by H2O2, PMA, LPS, okadaic acid, and ceramide. [1]

Name	Piceatannol
Synonyms	3,3',4'5-Tetrahydroxystilbene E-Piceatannol 1,2-Benzenediol, 4-[(E)-2-(3,5-dihydroxyphenyl)ethenyl]- 3,3′,4,5′-Tetrahydroxy-trans-stilbene 3,3',4,5'-Tetrahydroxy-trans-stilbene 3,4,3',5'-Tetrahydroxy-trans-stilbene 4-[(E)-2-(3,5-Dihydroxyphenyl)vinyl]benzene-1,2-diol 3,5,3',4'-tetrahydroxystilbene 4-[(E)-2-(3,5-Dihydroxyphenyl)vinyl]-1,2-benzenediol Piceatannol 4-[(E)-2-(3,5-dihydroxyphenyl)ethenyl]benzene-1,2-diol MFCD00221715 4-(2-(3,5-Dihydroxyphenyl)vinyl)-1,2-benzenediol (E)-4-[2-(3,5Dihydroxyphenyl)ethenyl]1,2-benzenediol (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol 5-[(E)-2-(3,4-Dihydroxyphenyl)vinyl]benzene-1,3-diol trans-3,3',4,5'-tetrahydroxystilbene 3,3',4,5'-tetrahydroxystilbene Piceatannol, (E)-

Description	Piceatannol is a selective inhibitor of protein tyrosine kinase Syk. It could inhibit ICa,L, Ito, IKr, Ca2+ transients and Na+-Ca2+ exchange except IK1. Shows multiple biological activities such as anti-inflammatory, antiproliferative and immunomodulatory effects.In vitro: The treatment of human myeloid cells with piceatannol suppressed TNF-induced DNA binding activity of NF-κB. The effect of piceatannol was not restricted to myeloid cells, as TNF-induced NF-κB activation was also suppressed in lymphocyte and epithelial cells. Piceatannol also inhibited NF-κB activated by H2O2, PMA, LPS, okadaic acid, and ceramide. [1]
Related Catalog	Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Syk Research Areas >> Cancer Natural Products >> Phenols
References	[1]. Kazuhiro Ashikawa et al. Piceatannol Inhibits TNF-Induced NF-κB Activation and NF-κB-Mediated Gene Expression Through Suppression of IκBα Kinase and p65 Phosphorylation. J Immunol, 2002 Dec 1, 169(11):6490-7. [2]. Wen-Pin Chen et al. Piceatannol, a derivative of resveratrol, moderately slows INa inactivation and exerts antiarrhythmic action in ischaemia-reperfused rat hearts. Br J Pharmacol.2009 Jun, 157(3), 381-391.

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases	24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2907299090

HS Code	2907299090
Summary	2907299090 polyphenols; phenol-alcohols。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:5.5%。general tariff:30.0%