BioBioPha
China
Product Name: (S)-10-Hydroxycamptothecin
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Purity: 98.0%
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: (S)-10-Hydroxycamptothecin
Price: ￥558.0/20mg ￥538.0/1g
Purity: 98.0%
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DC Chemicals Limited
China
Product Name: 10-Hydroxycamptothecin
Price: $280.0/20mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: (S)-10-Hydroxycamptothecin
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

19685-09-7

19685-09-7 structure

Name: (S)-10-Hydroxycamptothecin
Chemical Name: 10-Hydroxycamptothecin
CAS Number: 19685-09-7
Molecular Formula: C₂₀H₁₆N₂O₅
Molecular Weight: 364.351
Catalog: API Antineoplastic agents Natural source antineoplastic agents
Create Date: 2018-02-04 08:00:00
Modify Date: 2024-01-02 15:36:32
(S)-10-Hydroxycamptothecin is a clinical therapy agent against hepatoma.IC50 value:Target:In vitro: In vitro, the 10-hydroxycamptothecin nanosuspensions released the encapsulated drug with nearly zero-order kinetics, and the accumulative release reached 90% within 72 hours. In vitro cytotoxicity assay showed that the 10-hydroxycamptothecin nanosuspensions had significantly enhanced cytotoxicity against HepG2 cells compared to the commercially available 10-hydroxycamptothecin injections [1].In vivo: The in vivo study with H22 tumor-bearing mice and intravenous injection of the drug showed that in contrast to the 10-hydroxycamptothecin injections, the 10-hydroxycamptothecin nanosuspensions exhibited significantly enhanced biodistribution, particularly in the lung (393.40-fold AUC0–24 h, liver (192.35-fold AUC0–24 h, spleen (141.67-fold AUC0–24 h and tumor (64.21-fold AUC0–24 h. The 10-hydroxycamptothecin nanosuspensions also showed improved antitumor therapeutic efficacy over the injections (89.83% vs. 30.56%) [1].

Name	10-Hydroxycamptothecin
Synonyms	10-Hydroxycamptothecin 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4,9-dihydroxy-, (4S)- Hydroxycamptothecine 10-Hydroxy camptothecin 10-OH-camptothecin 10-hydroxy-CPT Camptothecin,hydroxy MFCD00189425 10-Hydroxycamptochecin Camptothecin, 10-hydroxy 10-hydroxy-Camptothecin (4S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione Hydroxycamptothecin 10-hydroxycamptothecine Irinotecan Related Compound A HCPT (S)-10-Hydroxycamptothecin

Description	(S)-10-Hydroxycamptothecin is a clinical therapy agent against hepatoma.IC50 value:Target:In vitro: In vitro, the 10-hydroxycamptothecin nanosuspensions released the encapsulated drug with nearly zero-order kinetics, and the accumulative release reached 90% within 72 hours. In vitro cytotoxicity assay showed that the 10-hydroxycamptothecin nanosuspensions had significantly enhanced cytotoxicity against HepG2 cells compared to the commercially available 10-hydroxycamptothecin injections [1].In vivo: The in vivo study with H22 tumor-bearing mice and intravenous injection of the drug showed that in contrast to the 10-hydroxycamptothecin injections, the 10-hydroxycamptothecin nanosuspensions exhibited significantly enhanced biodistribution, particularly in the lung (393.40-fold AUC0–24 h, liver (192.35-fold AUC0–24 h, spleen (141.67-fold AUC0–24 h and tumor (64.21-fold AUC0–24 h. The 10-hydroxycamptothecin nanosuspensions also showed improved antitumor therapeutic efficacy over the injections (89.83% vs. 30.56%) [1].
Related Catalog	Signaling Pathways >> Others >> Others Natural Products >> Alkaloid Research Areas >> Cancer
References	[1]. Min Liu, et al. Intracellular delivery of 10-hydroxycamptothecin with targeted nanostructured lipid carriers against multidrug resistance . Journal of Drug Targeting. [2]. Min Liu, et al. Intracellular delivery of 10-hydroxycamptothecin with targeted nanostructured lipid carriers against multidrug resistance. J Drug Target, Early Online: 1–8

Density	1.6±0.1 g/cm3
Boiling Point	820.7±65.0 °C at 760 mmHg
Melting Point	265-270°C
Molecular Formula	C₂₀H₁₆N₂O₅
Molecular Weight	364.351
Flash Point	450.1±34.3 °C
Exact Mass	364.105927
PSA	101.65000
LogP	1.32
Vapour Pressure	0.0±3.1 mmHg at 25°C
Index of Refraction	1.777
Storage condition	-20°C Freezer

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UQ0491700

CAS REGISTRY NUMBER :: 19685-09-7

LAST UPDATED :: 198305

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C20-H16-N2-O5.H2-O

MOLECULAR WEIGHT :: 382.40

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 104 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Human Cells - not otherwise specified

DOSE/DURATION :: 100 ug/L

REFERENCE :: YHHPAL Yaoxue Xuebao. Acta Pharmaceutica Sinica. Pharmaceutical Journal. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1953- Suspended 1966-78. Volume(issue)/page/year: 21,492,1986

RIDADR	NONH for all modes of transport
HS Code	2934999090

Precursor 7
7689-03-4 19685-10-0 870527-52-9 123948-88-9
173442-34-7 86639-48-7 623-51-8
DownStream 7
91421-42-0 91421-43-1 86639-52-3 19685-10-0
104267-73-4 123948-87-8 119413-54-6

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

19685-09-7	64439-81-2
1330277-66-1	185425-25-6
123948-91-4	6714-13-2
95033-74-2	866219-37-6
448897-05-0	117620-84-5