Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Huperzine B
Price: Check
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Huperzine B
Price: ￥588.0/20mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Liu jia
Email: 2130147988@qq.com

DC Chemicals Limited
China
Product Name: Huperzine B
Price: $280.0/20mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: H-LEU-LEU-LEU-OH
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

103548-82-9

103548-82-9 structure

103548-82-9 structure

Name: Huperzine B
Chemical Name: Huperzine B
CAS Number: 103548-82-9
Molecular Formula: C₁₆H₂₀N₂O
Molecular Weight: 256.343
Catalog: Biochemical Natural product
Create Date: 2018-06-19 17:50:04
Modify Date: 2025-08-25 10:39:43
Huperzine B is a Lycopodium alkaloid isolated from Huperzia serrata and a highly selective acetylcholinesterase (AChE) inhibitor. Huperzine B can be uesd to can be used to improve Alzheimer's disease[1][2].

Name	Huperzine B
Synonyms	HuperzineB (1R,9R,10R)-16-Methyl-6,14-diazatetracyclo[7.5.3.0.0]heptadeca-2(7),3,16-trien-5-one 1H-5,10b-[1]Propeno-1,7-phenanthrolin-8(7H)-one, 2,3,4,4a,5,6-hexahydro-12-methyl-, (4aR,5R,10bR)-

Description	Huperzine B is a Lycopodium alkaloid isolated from Huperzia serrata and a highly selective acetylcholinesterase (AChE) inhibitor. Huperzine B can be uesd to can be used to improve Alzheimer's disease[1][2].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> AChE
Target	AChE[1]
References	[1]. Zhang HY, et al. Huperzine B, a novel acetylcholinesterase inhibitor, attenuates hydrogen peroxide induced injury in PC12 cells. Neurosci Lett. 2000 Sep 29;292(1):41-4. [2]. He XC, et al. Study on dual-site inhibitors of acetylcholinesterase: Highly potent derivatives of bis- and bifunctional huperzine B. Bioorg Med Chem. 2007 Feb 1;15(3):1394-408.

Density	1.2±0.1 g/cm3
Boiling Point	533.5±50.0 °C at 760 mmHg
Molecular Formula	C₁₆H₂₀N₂O
Molecular Weight	256.343
Flash Point	216.4±30.3 °C
Exact Mass	256.157562
PSA	44.89000
LogP	1.98
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.624

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OL2780000

CHEMICAL NAME :: Lycodin-1(18H)-one, 8,15-didehydro-

CAS REGISTRY NUMBER :: 103548-82-9

LAST UPDATED :: 198912

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C16-H20-N2-O

MOLECULAR WEIGHT :: 256.38

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 43841 ug/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - lacrimation Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1980- Volume(issue)/page/year: 8,117,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 25125 ug/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - lacrimation Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1980- Volume(issue)/page/year: 8,117,1987

89-82-7 structure

89-82-7

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103548-82-9 structure

103548-82-9

107965-41-3 structure

107965-41-3

Literature: Journal of Organic Chemistry, , vol. 79, # 1 p. 240 - 250

1393110-52-5 structure

1393110-52-5

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103548-82-9 structure

103548-82-9

107965-41-3 structure

107965-41-3

Literature: Journal of Organic Chemistry, , vol. 79, # 1 p. 240 - 250

1393110-49-0 structure

1393110-49-0

~%

103548-82-9 structure

103548-82-9

107965-41-3 structure

107965-41-3

Literature: Journal of Organic Chemistry, , vol. 79, # 1 p. 240 - 250

156094-64-3 structure

156094-64-3

~%

103548-82-9 structure

103548-82-9

107965-41-3 structure

107965-41-3

Literature: Journal of Organic Chemistry, , vol. 79, # 1 p. 240 - 250

1391435-96-3 structure

1391435-96-3

~%

103548-82-9 structure

103548-82-9

107965-41-3 structure

107965-41-3

Literature: Journal of Organic Chemistry, , vol. 79, # 1 p. 240 - 250

1391436-01-3 structure

1391436-01-3

~%

103548-82-9 structure

103548-82-9

107965-41-3 structure

107965-41-3

Literature: Journal of Organic Chemistry, , vol. 79, # 1 p. 240 - 250

Precursor 3
89-82-7 1393110-49-0 1391436-01-3
DownStream 2
612-60-2 3279-76-3

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