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138112-76-2

138112-76-2 structure
138112-76-2 structure
  • Name: Agomelatine
  • Chemical Name: Agomelatine
  • CAS Number: 138112-76-2
  • Molecular Formula: C15H17NO2
  • Molecular Weight: 243.301
  • Catalog: API Nervous system medication Antidepressant, manic
  • Create Date: 2018-07-11 12:18:37
  • Modify Date: 2025-08-20 17:50:18
  • Agomelatine is a competitive antagonist of human and porcine serotonin (5-HT2C) receptors (pKi = 6.2 and 6.4, respectively) as well as human 5-HT2B receptors (pKi = 6.6). IC50 value: 6.2 (pKi, 5-HT2c); 6.6 (pKi, 5-HT2b)Target: 5-HT2C Receptor; 5-HT2B receptorIt is classified as a norepinephrine-dopamine disinhibitor (NDDI) due to its antagonism of the 5-HT2C receptor. Activation of 5-HT2C receptors by serotonin inhibits dopamine and norepinephrine release. Antagonism of 5-HT2C results in an enhancement of DA and NE release and activity of frontocortical dopaminergic and adrenergic pathways. Agomelatine is also a potent agonist at melatonin receptors which makes it the first melatonergic antidepressant. Agomelatine is an antidepressant drug.
Name Agomelatine
Synonyms Unii-137R1N49ad
N-[2-(7-Methoxy-1-naphthyl)ethyl]acetamide
Acetamide, N-[2-(7-methoxy-1-naphthalenyl)ethyl]-
Aglomelatine
Agomelatine
N-[2-(7-Methoxy-1-naphthalenyl)ethyl]-acetamide S-20098
AGOMELATIN
Valdoxan
N-(2-(7-Methoxynaphthalen-1-yl)ethyl)acetamide
N-[2-(7-Methoxy-1-naphthalenyl)ethyl]acetamide
Melitor
Thymanax
Description Agomelatine is a competitive antagonist of human and porcine serotonin (5-HT2C) receptors (pKi = 6.2 and 6.4, respectively) as well as human 5-HT2B receptors (pKi = 6.6). IC50 value: 6.2 (pKi, 5-HT2c); 6.6 (pKi, 5-HT2b)Target: 5-HT2C Receptor; 5-HT2B receptorIt is classified as a norepinephrine-dopamine disinhibitor (NDDI) due to its antagonism of the 5-HT2C receptor. Activation of 5-HT2C receptors by serotonin inhibits dopamine and norepinephrine release. Antagonism of 5-HT2C results in an enhancement of DA and NE release and activity of frontocortical dopaminergic and adrenergic pathways. Agomelatine is also a potent agonist at melatonin receptors which makes it the first melatonergic antidepressant. Agomelatine is an antidepressant drug.
Related Catalog
References

[1]. Pan L, Kardono LB, Riswan S, Chai H, Carcache de Blanco EJ, Pannell CM, Soejarto DD, McCloud TG, Newman DJ, Kinghorn AD.Isolation and characterization of minor analogues of silvestrol and other constituents from a large-scale re-collection of Aglaia foveolata.J Nat Prod. 2010 Nov 29;73(11):1873-8.

[2]. Zajecka J, Schatzberg A, Stahl S. et al. Efficacy and safety of agomelatine in the treatment of major depressive disorder: a multicenter, randomized, double-blind, placebo-controlled trial. J Clin Psychopharmacol. 2010 Apr;30(2):135-44.

[3]. Randy A Sansone, Lori A Sansone. Agomelatine A Novel Antidepressant. Innov Clin Neurosci. 2011 November; 8(11): 10-14.

[4]. Michele Fornaro, Davide Prestia, Salvatore Colicchio, and Giulio Perugi. A Systematic, Updated Review on the Antidepressant Agomelatine Focusing on its Melatonergic Modulation. Curr Neuropharmacol. 2010 September; 8(3): 287-304.

[5]. Agomelatine
Density 1.1±0.1 g/cm3
Boiling Point 478.8±28.0 °C at 760 mmHg
Melting Point 107-109ºC
Molecular Formula C15H17NO2
Molecular Weight 243.301
Flash Point 243.4±24.0 °C
Exact Mass 243.125931
PSA 38.33000
LogP 2.27
Vapour Pressure 0.0±1.2 mmHg at 25°C
Index of Refraction 1.582
Storage condition -20°C Freezer

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AC5956323
CHEMICAL NAME :
Acetamide, N-(2-(7-methoxy-1-naphthalenyl)ethyl)-
CAS REGISTRY NUMBER :
138112-76-2
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C15-H17-N-O2
MOLECULAR WEIGHT :
243.33

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #5318994
Symbol GHS09
GHS09
Signal Word Warning
Hazard Statements H400
Precautionary Statements P273
Hazard Codes N
Risk Phrases 50
Safety Phrases 61
RIDADR UN 3077 9 / PGIII
HS Code 2924199090
HS Code 2924299090
Summary 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
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