152302-45-9

152302-45-9 structure

Name: 7-Desmethylagomelatine
Chemical Name: N-[2-(7-hydroxynaphthalen-1-yl)ethyl]acetamide
CAS Number: 152302-45-9
Molecular Formula: C₁₄H₁₅NO₂
Molecular Weight: 229.274
Catalog: Research Areas Others
Create Date: 2018-12-04 05:40:50
Modify Date: 2025-08-24 20:39:54
7-Desmethyl-agomelatine is a metabolite of Agomelatine. Agomelatineis a potent agonist at melatonin receptors (MT1 and MT2), and also is an antagonist of 5-HT2C[1][2].

Name	N-[2-(7-hydroxynaphthalen-1-yl)ethyl]acetamide
Synonyms	Acetamide, N-[2-(7-hydroxy-1-naphthalenyl)ethyl]- 7-Demethyl-Agomelatine N-[2-(7-hydroxynaphthalen-1-yl)ethyl]acetamide N-[2-(7-Hydroxy-1-naphthyl)ethyl]acetamide N-(2-(7-hydroxy-1-naphthyl)ethyl)acetamide Agomelatine Impurity 12 7-Desmethylagomelatine

Description	7-Desmethyl-agomelatine is a metabolite of Agomelatine. Agomelatineis a potent agonist at melatonin receptors (MT1 and MT2), and also is an antagonist of 5-HT2C[1][2].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
References	[1]. Millan MJ, et al. The novel melatonin agonist agomelatine (S20098) is an antagonist at 5-hydroxytryptamine2C receptors, blockade of which enhances the activity of frontocortical dopaminergic and adrenergic pathways. J Pharmacol Exp Ther. 2003 Sep;306(3):954-64. [2]. Li M, et al. Development and validation a LC-MS/MS method for the simultaneous determination of agomelatine and its metabolites, 7-desmethyl-agomelatine and 3-hydroxy-agomelatine in human plasma: Application to a bioequivalence study. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Oct 15;1003:60-6.

Density	1.2±0.1 g/cm3
Boiling Point	511.3±33.0 °C at 760 mmHg
Molecular Formula	C₁₄H₁₅NO₂
Molecular Weight	229.274
Flash Point	263.0±25.4 °C
Exact Mass	229.110275
PSA	52.82000
LogP	1.62
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.624

HS Code	2924299090

138112-76-2

~79%

152302-45-9

Literature: Ettaoussi, Mohamed; Sabaouni, Ahmed; Rami, Marouan; Boutin, Jean A.; Delagrange, Philippe; Renard, Pierre; Spedding, Michael; Caignard, Daniel-Henri; Berthelot, Pascal; Yous, Said European Journal of Medicinal Chemistry, 2012 , vol. 49, p. 310 - 323

296280-78-9

152302-45-9

Literature: SYMED LABS LIMITED; MOHAN RAO, Dodda; ANNA REDDY, Ambati Patent: WO2014/64706 A1, 2014 ; Location in patent: Page/Page column 76 ;

139525-77-2

152302-45-9

Literature: Depreux; Lesieur; Mansour; Morgan; Howell; Renard; Caignard; Pfeiffer; Delagrange; Guardiola; Yous; Demarque; Adam; Andrieux Journal of Medicinal Chemistry, 1994 , vol. 37, # 20 p. 3231 - 3239

22009-38-7

152302-45-9

Literature: SYMED LABS LIMITED; MOHAN RAO, Dodda; ANNA REDDY, Ambati Patent: WO2014/64706 A1, 2014 ;

Precursor 4
138112-76-2 296280-78-9 139525-77-2 22009-38-7
DownStream 1
138112-76-2

HS Code	2924299090
Summary	2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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