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20183-47-5

20183-47-5 structure
20183-47-5 structure
  • Name: Tenuifolin
  • Chemical Name: (2β,3β)-3-(β-D-Glucopyranosyloxy)-2,27-dihydroxyolean-12-ene-23,2 8-dioic acid
  • CAS Number: 20183-47-5
  • Molecular Formula: C36H56O12
  • Molecular Weight: 680.823
  • Catalog: Biochemical Plant extracts
  • Create Date: 2018-08-12 16:42:33
  • Modify Date: 2025-08-24 17:11:39
  • Tenuifolin is a triterpene isolated from Polygala tenuifolia Willd, has neuroprotective effects. Tenuifolin reduces Aβ secretion by inhibiting β-secretase. Tenuifolin improves learning and memory in aged mice by decreasing AChE activity and has the potential for Alzheimer’s disease (AD) treatment[1].

Name (2β,3β)-3-(β-D-Glucopyranosyloxy)-2,27-dihydroxyolean-12-ene-23,2 8-dioic acid
Synonyms (2β,3β)-3-(β-D-Glucopyranosyloxy)-2,27-dihydroxyolean-12-ene-24,28-dioic acid
Olean-12-ene-23,28-dioic acid, 3-(β-D-glucopyranosyloxy)-2,27-dihydroxy-, (2β,3β)-
Tenuifolin
Olean-12-ene-24,28-dioic acid, 3-(β-D-glucopyranosyloxy)-2,27-dihydroxy-, (2β,3β)-
(2β,3β)-3-(β-D-Glucopyranosyloxy)-2,27-dihydroxyolean-12-ene-23,28-dioic acid
Description Tenuifolin is a triterpene isolated from Polygala tenuifolia Willd, has neuroprotective effects. Tenuifolin reduces Aβ secretion by inhibiting β-secretase. Tenuifolin improves learning and memory in aged mice by decreasing AChE activity and has the potential for Alzheimer’s disease (AD) treatment[1].
Related Catalog
Target

IC50: β-secretase; ACHE[1]

References

[1]. Ki-Yeol Yoo, et al. Terpenoids as Potential Anti-Alzheimer’s Disease Therapeutics. Molecules 2012, 17(3), 3524-3538

Density 1.4±0.1 g/cm3
Boiling Point 853.6±65.0 °C at 760 mmHg
Melting Point 201-204℃
Molecular Formula C36H56O12
Molecular Weight 680.823
Flash Point 262.2±27.8 °C
Exact Mass 680.377197
PSA 214.44000
LogP 2.25
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.623
Safety Phrases 24/25
HS Code 29389090
Precursor  2

DownStream  0

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