Name | 5-(3,4-dichlorophenyl)-6-methylpyrimidine-2,4-diamine |
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Synonyms |
METOPRINE,METHODICHLOROPHEN
BW-197U 2aov DDMP METOPRINE SK 5265 Methodichlorophen |
Description | Metoprine (BW 197U) is a potent histamine N-methyltransferase (HMT) inhibitor. Metoprine, a diaminopyrimidine derivative, can cross the blood-brain barrier and increase brain histamine levels by inhibiting HMT[1][2]. Metoprine is an antifolate and antitumor agent[3]. |
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Related Catalog | |
In Vivo | Metoprine (BW 197U; 2-10 mg/kg; IP) ameliorates the memory deficits induced by nucleus basalis magnocellularis (NBM) lesions in a dose-dependent manner[2]. Intraperitoneal administration of Metoprine produces various behavioral effects, including decreases in food intake and increases in water consumption[1]. Animal Model: Male Sprague-dawley rats (200-280g)[2] Dosage: 2, 5, 10 mg/kg Administration: IP Result: Ameliorated the memory deficits induced by nucleus basalis magnocellularis (NBM) lesions in a dose-dependent manner and significanty prolonged transfer latency at a high dose of 10 mg/kg. |
References |
Density | 1.447g/cm3 |
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Boiling Point | 483.7ºC at 760 mmHg |
Melting Point | 275-276ºC |
Molecular Formula | C11H10Cl2N4 |
Molecular Weight | 269.13000 |
Flash Point | 246.3ºC |
Exact Mass | 268.02800 |
PSA | 77.82000 |
LogP | 4.08560 |
Index of Refraction | 1.678 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
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Hazard Codes | Xi |
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