Zhejiang Hangyu API Co., Ltd
China
Product Name: Heparin
Price: ￥Inquiry/1kg
Purity: 99.5%
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Henan Tianfu Chemical Co., Ltd.
China
Product Name: Heparin
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

9005-49-6

9005-49-6 structure

Name: Heparin
Chemical Name: Heparin
CAS Number: 9005-49-6
Molecular Formula: C₂₆H₄₂N₂O₃₇S₅
Molecular Weight: 1134.93000
Catalog: API Blood system medication Anticoagulant and antiplatelet drugs
Create Date: 2018-02-05 08:00:00
Modify Date: 2024-01-02 21:05:55
Heparin is a highly sulfated glycosaminoglycan,that is widely used as an injectable anticoagulant, and has the highest negative charge density of any known biological molecule.

Name	Heparin
Synonyms	clarin thrombophob HED heparin liquaemin Enoxaparine pularin Depo heparin MFCD00081689 EINECS 232-681-7

Description	Heparin is a highly sulfated glycosaminoglycan,that is widely used as an injectable anticoagulant, and has the highest negative charge density of any known biological molecule.
Related Catalog	Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Others Natural Products >> Saccharides and Glycosides
Target	Human Endogenous Metabolite
In Vitro	Heparin is a potent anticoagulant drug based on its ability to accelerate the rate at which antithrombin inhibits serine proteases in the blood coagulation cascade. Heparin and the structurally related heparan sulfate are complex linear polymers comprised of a mixture of chains of different length, having variable sequences. Heparin interactes most tightly with peptides containing a complementary binding site of high positive charge density. Heparin and heparan sulfate predominantly exhibit linear helical secondary structures with sulfo and carboxyl groups displayed at defined intervals and in defined orientations along the polysaccharide backbone. Heparin resembles DNA as both are highly charged linear polymers that behave as polyelectrolytes. Heparin is believed to function as an anticoagulant primarily through its interaction with AT III by enhancing AT-III-mediated inhibition of blood coagulation factors, including thrombin and factor Xa. Heparin binds to AT III and thrombin in a ternary complex, increasing the bimolecular rate constant for the inhibition of thrombin by a factor of 2000. Heparin is principally located in the granules of tissue mast cells that are closely associated with the immune response. Heparin makes numerous contacts with both FGF-2 and FGFR-1 stabilizing FGF–FGFR binding. Heparin also makes contacts with the FGFR-1 of the adjacent FGF–FGFR complex, thus seeming to promote FGFR dimerization[1].
References	[1]. Capila I, et al. Heparin-protein interactions. Angew Chem Int Ed Engl. 2002 Feb 1;41(3):391-412.

Density	2.18 g/cm3
Boiling Point	644.9ºC at 760mmHg
Molecular Formula	C₂₆H₄₂N₂O₃₇S₅
Molecular Weight	1134.93000
Flash Point	343.8ºC
Exact Mass	1134.01000
PSA	652.39000
Index of Refraction	1.711
Water Solubility	H2O: 50 mg/mL, clear, faintly yellow

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MI0700000

CHEMICAL NAME :: Heparin

CAS REGISTRY NUMBER :: 9005-49-6

LAST UPDATED :: 199706

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 1857 units/kg/13D-I

TOXIC EFFECTS :: Cardiac - other changes Nutritional and Gross Metabolic - changes in potassium

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 1000 units/kg/5D-I

TOXIC EFFECTS :: Nutritional and Gross Metabolic - changes in potassium

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 3536 units/kg/13D-I

TOXIC EFFECTS :: Nutritional and Gross Metabolic - changes in potassium

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1950 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 420 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1900 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

DOSE :: 2857 units/kg

SEX/DURATION :: male 5 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - other effects on male

MUTATION DATA

TYPE OF TEST :: Unscheduled DNA synthesis

TEST SYSTEM :: Rodent - guinea pig Bone marrow

DOSE/DURATION :: 5 mg/L

REFERENCE :: FOBLAN Folia Biologica (Prague). (Academic Press Inc. Ltd., 24-28 Oval Rd., London NW1 7DX, UK) V.1- 1955- Volume(issue)/page/year: 16,196,1970 *** REVIEWS *** TOXICOLOGY REVIEW AEMBAP Advances in Experimental Medicine and Biology. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.1- 1967- Volume(issue)/page/year: 52,375,1975 TOXICOLOGY REVIEW JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 62,517,1973 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84488 No. of Facilities: 374 (estimated) No. of Industries: 3 No. of Occupations: 8 No. of Employees: 4525 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84488 No. of Facilities: 430 (estimated) No. of Industries: 4 No. of Occupations: 14 No. of Employees: 27273 (estimated) No. of Female Employees: 23149 (estimated)

Safety Phrases	24/25
WGK Germany	2
RTECS	MI0850000
HS Code	3001901000

9041-08-1

9005-49-6

Literature: Carbohydrate Research, , vol. 340, # 6 p. 1185 - 1191

HS Code	3001901000

9005-49-6	91449-79-5
9041-08-1	9025-39-2
37270-89-6	9005-48-5
54479-70-8	116111-09-2
81604-65-1	9045-22-1