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152-95-4

152-95-4 structure
152-95-4 structure
  • Name: Sophoricoside
  • Chemical Name: Sophoricoside
  • CAS Number: 152-95-4
  • Molecular Formula: C21H20O10
  • Molecular Weight: 432.378
  • Catalog: Biochemical Natural product
  • Create Date: 2018-09-29 21:12:33
  • Modify Date: 2024-01-02 18:57:23
  • Sophoricoside is an isoflavone glycoside isolated from Sophora japonica and has anti-inflammatory, anti-cancer and immunosuppressive effects.
Name Sophoricoside
Synonyms 4-(5,7-Dihydroxy-4-oxo-4H-chromen-3-yl)phenyl β-D-glucopyranoside
Genistein-4'-glucoside
4H-1-Benzopyran-4-one, 3-[4-(β-D-glucopyranosyloxy)phenyl]-5,7-dihydroxy-
Genistein 4'-Glucoside
4'-(β-D-Glucopyranosyloxy)-5,7-dihydroxyisoflavone
4H-1-Benzopyran-4-one,3-[4-(
4',5,7-Trihydroxyisoflavone-4'-D-glucoside
MFCD01075138
Sophoricoside
3-[4-(b-D-Glucopyranosyloxy)phenyl]-5,7-dihydroxy-411-1-benzopyran-4-one
Description Sophoricoside is an isoflavone glycoside isolated from Sophora japonica and has anti-inflammatory, anti-cancer and immunosuppressive effects.
Related Catalog
In Vitro Sophoricoside is an isoflavone glycoside isolated from Sophora japonica and has anti-inflammatory, anti-cancer and immunosuppressive effects. The results show that Sophoricoside (50 μM) significantly inhibits the PMACI-induced histamine release. The inhibition rate reaches up to 30.24%. The maximal rates of TNF-α, IL-8 and IL-6 inhibition by Sophoricoside (50 μM) are approximately 31.42%, 43.43% and 34.24%, respectively. The rates of the levels of Rel/p65 inhibition in nuclear by Sophoricoside (50 μM) is approximately 50.14%. Results show that the enhanced caspase-1 activity induced by PMACI is significantly reduced by Sophoricoside in a dose-dependent manner[1].
In Vivo When the Sophoricoside is orally administered 1 h before compound 48/80 injections, the scratching behaviors is reduced. The inhibition rate of Sophoricoside (2 mg/kg) is approximately 41.21%. Orally administered Sophoricoside inhibits the scratching behaviors by 47.31%. When mice are treated for 2 weeks with Sophoricoside, the atopic dermatitis is recovered to a significant extent[1].
Kinase Assay Cells are incubated with the Sophoricoside for 1 h, and then incubated with PMACI for 2 h. The reaction is stopped by cooling the tubes in ice. The cells are separated from the released histamine by centrifugation at 400×g for 5 min at 4°C. The histamine levels are measured by ELISA using a histamine assay kit according to the manufacturer’s directions. Duplicate aliquots of supernatant are measured for each sample[1].
Cell Assay To test the cell viability by each concentration of Sophoricoside, the MTT colorimetric assay is performed. Briefly, HMC-1 cells (3×105 cells/well) are incubated with Sophoricoside (1 to 50 μM) for 12 h. After the addition of MTT solution, the cells are incubated at 37°C for 4 h. The crystallized MTT (formazan) is dissolved in dimethyl sulfoxide and the absorbance is measured at 540 nm[1].
Animal Admin BALB/c mice (5 weeks, 19 to 20 g) are used in this study. The dorsal skin of the BALB/c mice (n=6) is shaved and treated with a depilatory prior to the experiment. The mice are sensitized with 100 μL of 0.15% DNCB in acetone-olive oil (3:1) applied to the dorsal skin twice per week for 5 weeks. Control mice receive vehicle (acetone/olive oil=3:1). After 3 weeks, Sophoricoside (2 mg/kg) is orally administered 2 weeks until the end of the experiment[1].
References

[1]. Kim SJ, et al. The ameliorative effect of sophoricoside on mast cell-mediated allergic inflammation in vivo and in vitro. Molecules. 2013 May 22;18(5):6113-27.
Density 1.6±0.1 g/cm3
Boiling Point 763.3±60.0 °C at 760 mmHg
Melting Point 285ºC
Molecular Formula C21H20O10
Molecular Weight 432.378
Flash Point 271.5±26.4 °C
Exact Mass 432.105652
PSA 170.05000
LogP 0.31
Vapour Pressure 0.0±2.7 mmHg at 25°C
Index of Refraction 1.717
Hazard Codes T,C
Risk Phrases R23/24/25:Toxic by inhalation, in contact with skin and if swallowed . R36/37/38:Irritating to eyes, respiratory system and skin .
Safety Phrases S26-S36-S45-S24/25
RIDADR UN 3276 6.1/PG 3
WGK Germany 3
RTECS AL7970000
Packaging Group II
Hazard Class 8
446-72-0 structure

446-72-0

~%

152-95-4 structure

152-95-4
Literature: Acta Chimica Academiae Scientiarum Hungaricae, , vol. 4, p. 383,384, 386
874532-59-9 structure

874532-59-9

~%

152-95-4 structure

152-95-4
Literature: Acta Chimica Academiae Scientiarum Hungaricae, , vol. 4, p. 383,384, 386

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title: CAS No. 152-95-4 | Chemsrc address: https://www.chemsrc.com/en/baike/830471.html

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