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11114-20-8

11114-20-8 structure
11114-20-8 structure
  • Name: Carrageenan
  • Chemical Name: κ-carrageenan
  • CAS Number: 11114-20-8
  • Molecular Formula: C24H36O25S2--
  • Molecular Weight: 788.65800
  • Catalog: Biochemical Carbohydrate Polysaccharide
  • Create Date: 2018-05-14 08:00:00
  • Modify Date: 2024-01-02 21:22:16
  • κ-Carrageenan is a natural polymer which predominantly available in red seaweeds. κ-Carrageenan is an effective drug carrier to deliver curcumin in cancer cells and to induce apoptosis. κ-carrageenan serves as a potential inflammatory agent that magnifies existing intestinal inflammation[1][2].
Name κ-carrageenan
Description κ-Carrageenan is a natural polymer which predominantly available in red seaweeds. κ-Carrageenan is an effective drug carrier to deliver curcumin in cancer cells and to induce apoptosis. κ-carrageenan serves as a potential inflammatory agent that magnifies existing intestinal inflammation[1][2].
Related Catalog
In Vitro κ-Car- Curcumin (Cur) (0-500 μg/mL; 24-72 hours) effectively involves in cancer cell growth inhibition at lower concentrations of 40 µg/mL[1]. The cytotoxicity of the Cur loaded κ-Car has a significantly high apoptotic activity in selected lung cancer cells of A549[1]. κ-Carrageenan (1-60 μg/mL; 0.5-24 hours) enhances LPS-induced IL-8 secretion in HT-29 cells[2]. Cell Viability Assay[1] Cell Line: A549 cells Concentration: 0-500 μg/mL Incubation Time: 24, 48 and 72 hours Result: The dose response effects of cells treated with Cur loaded κ-Car after incubation of 24, 48 and 72 h exhibited a significant IC50 values of 65, 50 and 40 μg/mL respectively, for 24, 48, 72 h ours.
In Vivo κ-Carrageenan (1.7-41.7 mg/kg; p.o. for 1 week prior to C. freundii DBS100 treatment) can synergistically activate LPS-induced inflammatory through the Bcl10-NF-κB pathway, as indicated by its aggravation of C. freundii DBS100-induced colitis in mice[2]. κ-Carrageenan enhances the C. freundii DBS100-dependent induction of TLR4 and NF-κB in the intestinal mucosa of infected mice[2]. κ-Carrageenan aggravated the TNBS-induced intestinal inflammation, and such an effect could be associated with the oxidative stress and activation of TLR4-NF-κB and MAPK/ERK1/2 pathway[3] Animal Model: Male and female NIH (s) mice[2] Dosage: 1.7 mg/kg, LOW; 8.3 mg/kg, MED; or 41.7 mg/kg, HIG Administration: Orally administered for 1 week prior to C. freundii DBS100 treatment Result: Enhanced the C. freundii DBS100-dependent induction of TLR4 and NF-κB in the intestinal mucosa of infected mice.
References

[1]. Sathuvan M, et al. κ-Carrageenan: An effective drug carrier to deliver curcumin in cancer cells and to induce apoptosis. Carbohydr Polym. 2017;160:184-193.

[2]. Wu W, et al. κ-Carrageenan Enhances Lipopolysaccharide-Induced Interleukin-8 Secretion by Stimulating the Bcl10-NF-κB Pathway in HT-29 Cells and Aggravates C. freundii-Induced Inflammation in Mice. Mediators Inflamm. 2017;2017:8634865.

[3]. Wei W, et al. Enhanced effect of κ-carrageenan on TNBS-induced inflammation in mice. Int Immunopharmacol. 2016;39:218-228.
Molecular Formula C24H36O25S2--
Molecular Weight 788.65800
Exact Mass 788.09900
PSA 394.53000
Appearance Solid | White to almost white to yellow to brownish
Water Solubility H2O: 5 mg/mL hot, soluble
Hazard Codes F+
RIDADR NONH for all modes of transport
WGK Germany 2
RTECS FI0704000

Chemsrc provides CAS#:11114-20-8 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 11114-20-8 | Chemsrc address: https://www.chemsrc.com/en/baike/828898.html

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