Carrageenan

Modify Date: 2024-01-02 21:22:16

Carrageenan structure	Common Name	Carrageenan
	CAS Number	11114-20-8	Molecular Weight	788.65800
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₄H₃₆O₂₅S₂--	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	N/A

Use of Carrageenan

κ-Carrageenan is a natural polymer which predominantly available in red seaweeds. κ-Carrageenan is an effective drug carrier to deliver curcumin in cancer cells and to induce apoptosis. κ-carrageenan serves as a potential inflammatory agent that magnifies existing intestinal inflammation[1][2].

Name	κ-carrageenan

Description	κ-Carrageenan is a natural polymer which predominantly available in red seaweeds. κ-Carrageenan is an effective drug carrier to deliver curcumin in cancer cells and to induce apoptosis. κ-carrageenan serves as a potential inflammatory agent that magnifies existing intestinal inflammation[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
In Vitro	κ-Car- Curcumin (Cur) (0-500 μg/mL; 24-72 hours) effectively involves in cancer cell growth inhibition at lower concentrations of 40 µg/mL[1]. The cytotoxicity of the Cur loaded κ-Car has a significantly high apoptotic activity in selected lung cancer cells of A549[1]. κ-Carrageenan (1-60 μg/mL; 0.5-24 hours) enhances LPS-induced IL-8 secretion in HT-29 cells[2]. Cell Viability Assay[1] Cell Line: A549 cells Concentration: 0-500 μg/mL Incubation Time: 24, 48 and 72 hours Result: The dose response effects of cells treated with Cur loaded κ-Car after incubation of 24, 48 and 72 h exhibited a significant IC50 values of 65, 50 and 40 μg/mL respectively, for 24, 48, 72 h ours.
In Vivo	κ-Carrageenan (1.7-41.7 mg/kg; p.o. for 1 week prior to C. freundii DBS100 treatment) can synergistically activate LPS-induced inflammatory through the Bcl10-NF-κB pathway, as indicated by its aggravation of C. freundii DBS100-induced colitis in mice[2]. κ-Carrageenan enhances the C. freundii DBS100-dependent induction of TLR4 and NF-κB in the intestinal mucosa of infected mice[2]. κ-Carrageenan aggravated the TNBS-induced intestinal inflammation, and such an effect could be associated with the oxidative stress and activation of TLR4-NF-κB and MAPK/ERK1/2 pathway[3] Animal Model: Male and female NIH (s) mice[2] Dosage: 1.7 mg/kg, LOW; 8.3 mg/kg, MED; or 41.7 mg/kg, HIG Administration: Orally administered for 1 week prior to C. freundii DBS100 treatment Result: Enhanced the C. freundii DBS100-dependent induction of TLR4 and NF-κB in the intestinal mucosa of infected mice.
References	[1]. Sathuvan M, et al. κ-Carrageenan: An effective drug carrier to deliver curcumin in cancer cells and to induce apoptosis. Carbohydr Polym. 2017;160:184-193. [2]. Wu W, et al. κ-Carrageenan Enhances Lipopolysaccharide-Induced Interleukin-8 Secretion by Stimulating the Bcl10-NF-κB Pathway in HT-29 Cells and Aggravates C. freundii-Induced Inflammation in Mice. Mediators Inflamm. 2017;2017:8634865. [3]. Wei W, et al. Enhanced effect of κ-carrageenan on TNBS-induced inflammation in mice. Int Immunopharmacol. 2016;39:218-228.

Molecular Formula	C₂₄H₃₆O₂₅S₂--
Molecular Weight	788.65800
Exact Mass	788.09900
PSA	394.53000
Appearance of Characters	Solid \| White to almost white to yellow to brownish
Water Solubility	H2O: 5 mg/mL hot, soluble

Hazard Codes	F+
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	FI0704000

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