92264-81-8

92264-81-8 structure

Name: Hydroxybupropion
Chemical Name: Hydroxybupropione
CAS Number: 92264-81-8
Molecular Formula: C₁₃H₁₈ClNO₂
Molecular Weight: 255.74100
Catalog: analytical chemistry Standard standard material
Create Date: 2018-08-17 12:51:28
Modify Date: 2025-08-25 18:07:25
Hydroxybupropion is the major active metabolite of Bupropion. Hydroxybupropion is metabolized by CYP2B6.Bupropion is an atypical antidepressant and smoking-cessation agent. Hydroxybupropion inhibits norepinephrine uptake with an IC50 value of 1.7 μM. Hydroxybupropion is also a nACh receptor antagonis tis more potent than Bupropion[1] .

Name	Hydroxybupropione
Synonyms	Hydroxybupropion

Description	Hydroxybupropion is the major active metabolite of Bupropion. Hydroxybupropion is metabolized by CYP2B6.Bupropion is an atypical antidepressant and smoking-cessation agent. Hydroxybupropion inhibits norepinephrine uptake with an IC50 value of 1.7 μM. Hydroxybupropion is also a nACh receptor antagonis tis more potent than Bupropion[1] .
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Signaling Pathways >> Neuronal Signaling >> nAChR Research Areas >> Neurological Disease
Target	IC50: 1.7 μM (Norepinephrine uptake)[1] nACh receptor[1]
References	[1]. Damaj MI, et al. Enantioselective effects of hydroxy metabolites of bupropion on behavior and on function of monoamine transporters and nicotinic receptors. Mol Pharmacol. 2004 Sep;66(3):675-82.

34911-51-8

124-68-5

~55%

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Literature: SOSEI R and D LTD. Patent: WO2007/102008 A1, 2007 ; Location in patent: Page/Page column 8 ;

34841-39-9

92264-81-8

Literature: European Journal of Clinical Pharmacology, , vol. 59, # 5-6 p. 429 - 442

766-84-7

92264-81-8

Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 7, # 1 p. 1 - 6

535-80-8

92264-81-8

Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 7, # 1 p. 1 - 6

34841-35-5

124-68-5

92264-81-8

Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 7, # 1 p. 1 - 6

HS Code	2922509090
Summary	2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%