210755-45-6
210755-45-6 structure
- Name: CP-471474
- Chemical Name: 2-[[4-(4-fluorophenoxy)phenyl]sulfonylamino]-N-hydroxy-2-methylpropanamide
- CAS Number: 210755-45-6
- Molecular Formula: C16H17FN2O5S
- Molecular Weight: 368.38000
- Catalog: Signaling Pathways Metabolic Enzyme/Protease MMP
- Create Date: 2016-12-21 20:28:51
- Modify Date: 2025-08-29 22:05:41
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CP-471474 is an orally active and pan MMP inhibitor, with IC50 values of 1170 nM (MMP-1), 0.7 nM (MMP-2), 16 nM (MMP-3), 13 nM (MMP-9) and 0.9 nM (MMP-13), respectively[1][2].
| Name | 2-[[4-(4-fluorophenoxy)phenyl]sulfonylamino]-N-hydroxy-2-methylpropanamide |
|---|---|
| Synonyms |
2-[[[4-(4-Fluorophenoxy)phenyl]sulfonyl]amino]-N-hydrox y-2-methylpropanamide PF-1626077
HMS3262O11 UNII-96U47H947L |
| Description | CP-471474 is an orally active and pan MMP inhibitor, with IC50 values of 1170 nM (MMP-1), 0.7 nM (MMP-2), 16 nM (MMP-3), 13 nM (MMP-9) and 0.9 nM (MMP-13), respectively[1][2]. |
|---|---|
| Related Catalog | |
| Target |
MMP-2:0.7 nM (IC50) MMP-13:0.9 nM (IC50) MMP-9:13 nM (IC50) MMP-3:16 nM (IC50) MMP-1:1170 nM (IC50) |
| In Vivo | CP-471474 plasma levels following subcutaneous injection are 2,020 ng/mL (1 h postdose) to 160 ng/mL (6 h postdose)[2]. CP-471,474 significantly reduces both the extent and severity of inflammation at 2 months. At 4 months, a spontaneous reduction of the inflammatory response is observed in both treated and untreated animals, and consequently no difference is observed between both[2]. CP-471474 significantly decreases the destructive lesions mainly at 2 months and also at 4 months[2]. Animal Model: Guinea pigs weighing 400 to 450 g (COPD)[2]. Dosage: 20 mg/kg (also supplemented daily by the diet (200 mg/200 g powdered chow)). Administration: Subcutaneously (in 20% ethanol/80% polyethylene glycol), once a day during the entire course. Result: Lungs derived from smoking animals treated with the compound demonstrated a statistically significant reduction in the destructive lesions. Showed an increase of both pro–MMP-9 and its active form (lanes 5 to 8) as compared with control animals. |
| References |
| Molecular Formula | C16H17FN2O5S |
|---|---|
| Molecular Weight | 368.38000 |
| Exact Mass | 368.08400 |
| PSA | 116.60000 |
| LogP | 4.49230 |
