DC Chemicals Limited
China
Product Name: Succinyl phosphonate
Price: $200.0/100mg $400.0/250mg $800.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Succinyl phosphonate
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

26647-82-5

26647-82-5 structure

26647-82-5 structure

Name: Succinyl phosphonate
Chemical Name: 4-oxo-4-phosphonobutanoic acid
CAS Number: 26647-82-5
Molecular Formula: C₄H₇O₆P
Molecular Weight: 182.06900
Catalog: Research Areas Others
Create Date: 2016-06-06 20:56:04
Modify Date: 2024-01-13 19:37:10
Succinyl phosphonate is an inhibitor of the α-ketoglutarate dehydrogenase.

Name	4-oxo-4-phosphonobutanoic acid
Synonyms	Butanoic acid,4-oxo-4-phosphono succinyl phosphonate

Description	Succinyl phosphonate is an inhibitor of the α-ketoglutarate dehydrogenase.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Others
In Vitro	Succinyl phosphonate is an α-Ketoglutarate phosphoanalogue. It is found to be an effective inhibitor of α-ketoglutarate oxidative decarboxylation, catalyzed by both muscle and bacterial α-ketoglutarate dehydrogenase complexes, as well as muscle α-ketoglutarate dehydrogenase[1]. At a concentration of 0.01 mM, succinyl phosphonate completely inhibits isolated brain KGDHC even in the presence of a 200-fold higher concentration of its substrate. In cultured human fibroblasts, 0.01 mM succinyl phosphonate produced 70% inhibition of α-ketoglutarate dehydrogenase complex. DESP and TESP are also inhibitory in the cell system, but only after preincubation, suggesting the release of their charged groups by cellular esterases[2]. Succinyl phosphonate inhibits 2-Oxoglutarate dehydrogenase , the first rate-limiting component of the mitochondrial multi-enzyme complex of oxidative decarboxylation of 2-oxoglutarate, in a highly selective and efficient manner[3].
Cell Assay	MTT assay is employed to test cellular viability. Serial dilutions of succinyl phosphonate (0.01-20 mM) are added to cells in fresh culture media. During the medium exchange before the succinyl phosphonate addition, glioblastoma cells are brought to DMEM with 1 g/L glucose, 1 mM pyruvate and 2 mM glutamax. The influence of succinyl phosphonate in minimal medium is studied in the earlier employed buffered salt solution[3].
References	[1]. Biryukov AI, et al. Succinyl phosphonate inhibits alpha-ketoglutarate oxidative decarboxylation, catalyzed by alpha-ketoglutarate dehydrogenase complexes from E. coli and pigeon breast muscle. FEBS Lett. 1996 Mar 11;382(1-2):167-70. [2]. Bunik VI, et al. Phosphonate analogues of alpha-ketoglutarate inhibit the activity of the alpha-ketoglutaratedehydrogenase complex isolated from brain and in cultured cells. Biochemistry. 2005 Aug 9;44(31):10552-61. [3]. Bunik VI, et al. Inhibition of mitochondrial 2-oxoglutarate dehydrogenase impairs viability of cancer cells in a cell-specific metabolism-dependent manner. Oncotarget. 2016 May 3;7(18):26400-21.

Molecular Formula	C₄H₇O₆P
Molecular Weight	182.06900
Exact Mass	181.99800
PSA	121.71000
Storage condition	2-8℃