Succinyl phosphonate
Modify Date: 2025-08-22 16:52:58
Succinyl phosphonate structure
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Common Name | Succinyl phosphonate | ||
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| CAS Number | 26647-82-5 | Molecular Weight | 182.06900 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C4H7O6P | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Succinyl phosphonateSuccinyl phosphonate is an inhibitor of the α-ketoglutarate dehydrogenase. |
| Name | 4-oxo-4-phosphonobutanoic acid |
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| Synonym | More Synonyms |
| Description | Succinyl phosphonate is an inhibitor of the α-ketoglutarate dehydrogenase. |
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| Related Catalog | |
| In Vitro | Succinyl phosphonate is an α-Ketoglutarate phosphoanalogue. It is found to be an effective inhibitor of α-ketoglutarate oxidative decarboxylation, catalyzed by both muscle and bacterial α-ketoglutarate dehydrogenase complexes, as well as muscle α-ketoglutarate dehydrogenase[1]. At a concentration of 0.01 mM, succinyl phosphonate completely inhibits isolated brain KGDHC even in the presence of a 200-fold higher concentration of its substrate. In cultured human fibroblasts, 0.01 mM succinyl phosphonate produced 70% inhibition of α-ketoglutarate dehydrogenase complex. DESP and TESP are also inhibitory in the cell system, but only after preincubation, suggesting the release of their charged groups by cellular esterases[2]. Succinyl phosphonate inhibits 2-Oxoglutarate dehydrogenase , the first rate-limiting component of the mitochondrial multi-enzyme complex of oxidative decarboxylation of 2-oxoglutarate, in a highly selective and efficient manner[3]. |
| Cell Assay | MTT assay is employed to test cellular viability. Serial dilutions of succinyl phosphonate (0.01-20 mM) are added to cells in fresh culture media. During the medium exchange before the succinyl phosphonate addition, glioblastoma cells are brought to DMEM with 1 g/L glucose, 1 mM pyruvate and 2 mM glutamax. The influence of succinyl phosphonate in minimal medium is studied in the earlier employed buffered salt solution[3]. |
| References |
| Molecular Formula | C4H7O6P |
|---|---|
| Molecular Weight | 182.06900 |
| Exact Mass | 181.99800 |
| PSA | 121.71000 |
| Storage condition | 2-8℃ |
| Butanoic acid,4-oxo-4-phosphono |
| succinyl phosphonate |