864167-45-3

864167-45-3 structure

Name: Succinyl phosphonate trisodium salt
Chemical Name: Succinyl phosphonate trisodium salt
CAS Number: 864167-45-3
Molecular Formula: C₄H₄Na₃O₆P
Molecular Weight: 248.01
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK ROS
Create Date: 2019-09-11 17:41:03
Modify Date: 2025-08-25 20:11:27
Succinyl phosphonate trisodium salt (SP) is an α-ketoglutarate dehydrogenase (KGDHC) inhibitor, effective inhibits (KGDHC) in muscle, bacterial, brain, and cultured human fibroblasts[1][4].Succinyl phosphonate trisodium salt (SP) is an 2-Oxoglutarate dehydrogenase (OGDH) inhibitor, impairs viability of cancer cells in a cell-specific metabolism-dependent manner[2].Succinyl phosphonate trisodium salt (SP) inhibits the glutamate-induced ROS production in glutamate-stimulated hippocampal neurons in situ[3].

Name	Succinyl phosphonate trisodium salt

Description	Succinyl phosphonate trisodium salt (SP) is an α-ketoglutarate dehydrogenase (KGDHC) inhibitor, effective inhibits (KGDHC) in muscle, bacterial, brain, and cultured human fibroblasts[1][4].Succinyl phosphonate trisodium salt (SP) is an 2-Oxoglutarate dehydrogenase (OGDH) inhibitor, impairs viability of cancer cells in a cell-specific metabolism-dependent manner[2].Succinyl phosphonate trisodium salt (SP) inhibits the glutamate-induced ROS production in glutamate-stimulated hippocampal neurons in situ[3].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ROS Research Areas >> Metabolic Disease Research Areas >> Neurological Disease
References	[1]. Biryukov AI, et al. Succinyl phosphonate inhibits alpha-ketoglutarate oxidative decarboxylation, catalyzed by alpha-ketoglutarate dehydrogenase complexes from E. coli and pigeon breast muscle. FEBS Lett. 1996 Mar 11;382(1-2):167-70. [2]. Bunik VI, et al. Inhibition of mitochondrial 2-oxoglutarate dehydrogenase impairs viability of cancer cells in a cell-specific metabolism-dependent manner. Oncotarget. 2016 May 3;7(18):26400-21. [3]. Zündorf G, et al. alpha-Ketoglutarate dehydrogenase contributes to production of reactive oxygen species in glutamate-stimulated hippocampal neurons in situ. Neuroscience. 2009 Jan 23;158(2):610-6. [4]. Bunik VI, et al. Phosphonate analogues of alpha-ketoglutarate inhibit the activity of the alpha-ketoglutarate dehydrogenase complex isolated from brain and in cultured cells. Biochemistry. 2005 Aug 9;44(31):10552-61.

Molecular Formula	C₄H₄Na₃O₆P
Molecular Weight	248.01

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

864167-45-3	26647-82-5
13708-85-5	10361-89-4
66019-20-3	1448858-83-0
320573-06-6	93919-41-6
114456-61-0	74812-64-9
1243370-50-4	1243455-95-9
1822612-82-7	2229379-14-8
1211536-44-5	1352397-38-6
1276601-58-1	1856878-25-5
934606-28-7	1243279-38-0