911-40-0

911-40-0 structure

Name: 7-Keto-3α,12-α-dihydroxycholanic Acid
Chemical Name: 3α,12α-dihydroxy-7-oxo-5β-cholanic acid
CAS Number: 911-40-0
Molecular Formula: C₂₄H₃₈O₅
Molecular Weight: 406.55600
Catalog: Research Areas Others
Create Date: 2018-12-26 16:09:50
Modify Date: 2025-09-18 22:24:23
7-keto-lithocholic acid is a metabolite of bile acids in Clostridium absonum. 7-keto-lithocholic acid is also converted from Lactobacillus and Bifidobacterium with specific condition[1][2].

Name	3α,12α-dihydroxy-7-oxo-5β-cholanic acid
Synonyms	(3alpha,5beta,12alpha)-3,12-Dihydroxy-7-oxocholan-24-oic acid 7-Ketodeoxycholic acid 7-ketodeoxycholate (4R)-4-[(3R,5S,8R,9S,10S,12S,13R,14S,17R)-3,12-dihydroxy-10,13-dimethyl-7-oxo-1,2,3,4,5,6,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]pentanoic acid 7-oxodeoxycholate 3alpha,12alpha-Diol-7-one-5beta-cholanoic acid 3alpha,12alpha-Dihydroxy-7-oxo-5beta-cholan-24-oic Acid 7-Oxodeoxycholic acid 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanic acid 3a,12a-dihydroxy-7-oxo-5b-cholan-24-oic acid 7-Keto-3α,12-α-dihydroxycholanic Acid

Description	7-keto-lithocholic acid is a metabolite of bile acids in Clostridium absonum. 7-keto-lithocholic acid is also converted from Lactobacillus and Bifidobacterium with specific condition[1][2].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
In Vitro	7-keto-lithocholic acid shows an increasing bioconversion rate with addition of an equimolar concentration of deoxycholic acid (which itself is not metabolized)[1]. 7-keto-lithocholic acid is induced by deoxycholic acid and then it's metabolized[1]. E. lentum-like c-25 converts 81.7% of 2 mM cholic acid to deoxycholic acid and 3.7% to 7-keto-deoxycholic acid under anaerobic incubation[2]. E. lentum-like c-25 converts 91.5% of 150 mg/mL cholic acid to deoxycholic acid and 1.1% to 7-keto-deoxycholic acid under anaerobic incubation[2].
References	[1]. Sutherland JD, et al. The metabolism of primary, 7-oxo, and 7 beta-hydroxy bile acids by Clostridium absonum. J Lipid Res. 1982 Jul;23(5):726-32. [2]. Takahashi T, et al. Absence of cholic acid 7 alpha-dehydroxylase activity in the strains of Lactobacillus and Bifidobacterium. J Dairy Sci. 1994 Nov;77(11):3275-86.

Hazard Codes	T

Precursor 0
DownStream 3
81-25-4 2955-27-3 133181-57-4