911-40-0

• 常用中文名：7-酮-3α,12-α-二羟基胆酸
• 常用英文名：7-Keto-3α,12-α-dihydroxycholanic Acid
• CAS号：911-40-0
• 分子式：C₂₄H₃₈O₅
• 分子量：406.55600
• 相关类别： 研究领域 其他
• 发布时间：2018-12-26 16:09:50
• 更新时间：2026-07-02 06:22:58
• 7-酮-石胆酸是绝对梭菌中胆汁酸的代谢物。7-酮-石胆酸也在特定条件下由乳酸杆菌和双歧杆菌转化[1][2]。

名称

• 中文名: 7-酮基-3alpha,12alpha-二羟基胆烷酸
• 英文名: 3α,12α-dihydroxy-7-oxo-5β-cholanic acid
• 中文别名: 7-酮-3Α,12-Α-二羟基胆酸; 胆酸杂质15(7-酮脱氧胆酸); (R)-4-((3R,5S,8R,9S,10S,12S,13R,14S,17R)-3,12-二羟基-10,13-二甲基-7-氧代十六氢-1H-环戊二烯并并[A]菲-17-基)戊酸; 3,12-二羟基-7-氧代胆烷-24-酸; 7 -酮-3Α,12-Α-羟基烷酸; 7-酮基-3α,12-α-二羟基胆酸; 7-酮-3Α(12-Α–羟基胆烷酸); 胆酸杂质12(7-酮脱氧胆酸); 7-脱氢胆酸; 7 -酮-3Α,12-Α-羟基胆烷酸; 7-酮-3ALPHA,12-ALPHA-二羟基胆酸; 3,12-二羟基-7-羰基卓兰-24-酸; 7-酮基-3ALPHA,12ALPHA-二羟基胆烷酸; 7-酮基-3Α,12Α-二羟基胆烷酸; 乙腈中7-酮基石胆酸标准溶液; 7-酮-3Α,12-Α-二羟基胆酸,10 MM DMSO 溶液; 7-酮-3Α,12-Α-羟基烷酸; 7-酮基-3ALPHA,12ALPHA-二羟基胆烷酸 标准品; 7-酮基-3A,12A-二羟基胆烷酸; 7-酮脱氧胆酸
• 英文别名: Deoxycholic Acid 7-Oxo Impurity; Cholan-24-oic acid,3,12-dihydroxy-7-oxo-, (3a,5b,12a); 5-BETA-CHOLANIC ACID-3-ALPHA, 12-ALPHA-DIOL-7-ONE; 7-Ketodeoxycholic acid; 7-Oxodeoxycholic acid; 7-DEHYDROCHOLIC ACID; 7-Oxodeoxycholic Acid; Cholan-24-oic acid, 3,12-dihydroxy-7-oxo-, (3α,5β,12α); 7-ketodeoxycholate; 5β-Cholanic Acid-3α,12α-diol-7-one; 5β-CHOLANIC acid-3α, 12α-DIOL-7-ONE; Cholic Acid Impurity 15 (7-Ketodeoxycholic Acid); Ursodeoxycholic Acid Impurity 11; 3a,12a-dihydroxy-7-oxo-5b-cholan-24-oic acid; 7-oxodeoxycholate; 3alpha,12alpha-Dihydroxy-7-oxo-5beta-cholan-24-oic Acid; 3alpha,12alpha-Diol-7-one-5beta-cholanoic acid; 3,12-DIHYDROXY-7-OXOCHOLAN-24-OIC ACID; 7-KETODEOXYCHOLIC ACID; (4R)-4-((3R,8R,9S,10S,12S,13R,14S,17R)-3,12-dihydroxy-10,13-dimethyl-7-oxohexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid; (3alpha,5beta,12alpha)-3,12-Dihydroxy-7-oxocholan-24-oic acid; 7-Ketodeoxycholic acida; 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanic acid; 7-keto-deoxycholic acid, 10 mM in DMSO; Cholic Acid Impurity 12 (7-Ketodeoxycholic Acid); (4R)-4-[(3R,5S,8R,9S,10S,12S,13R,14S,17R)-3,12-dihydroxy-10,13-dimethyl-7-oxo-1,2,3,4,5,6,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]pentanoic acid; 3α,12α-dihydroxy-7-keto-5β-cholan-24-oic acid; 3α,12α-Dihydroxy-7-keto-5β-cholanic Acid; 7-Keto-3alpha,12alpha-dihydroxycholanic acid; (3α,5β,12α)-3,12-Dihydroxy-7-oxo-cholan-24-oic Acid; (R)-4-((3R,5S,8R,9S,10S,12S,13R,14S,17R)-3,12-Dihydroxy-10,13-dimethyl-7-oxohexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid

物化性质

• 密度: 1.18g/cm3
• 沸点: 583ºC at 760mmHg
• 熔点: 54-60ºC
• 分子式: C₂₄H₃₈O₅
• 分子量: 406.55600
• 闪点: 320.4ºC
• 精确质量: 406.27200
• PSA: 94.83000
• LogP: 3.65690
• 折射率: 1.55
• 储存条件: 室温

生物活性

• 描述: 7-酮-石胆酸是绝对梭菌中胆汁酸的代谢物。7-酮-石胆酸也在特定条件下由乳酸杆菌和双歧杆菌转化[1][2]。
• 相关类别:
  研究领域 >> 其他
  信号通路 >> 其他 >> 其他
• 体外研究: 7-酮-石胆酸在添加等摩尔浓度的脱氧胆酸(其本身未被代谢)时显示出增加的生物转化率[1]。7-酮-石胆酸由脱氧胆酸诱导,然后进行代谢[1]。E、 lentum样c-25在厌氧培养下将81.7%的2mM胆酸转化为脱氧胆酸,将3.7%转化为7-酮基脱氧胆酸[2]。E、 lentum样c-25在厌氧培养下将91.5%的150 mg/mL胆酸转化为脱氧胆酸,并将1.1%转化为7-酮基脱氧胆酸[2]。
• 参考文献:

  [1]. Sutherland JD, et al. The metabolism of primary, 7-oxo, and 7 beta-hydroxy bile acids by Clostridium absonum. J Lipid Res. 1982 Jul;23(5):726-32.

  [2]. Takahashi T, et al. Absence of cholic acid 7 alpha-dehydroxylase activity in the strains of Lactobacillus and Bifidobacterium. J Dairy Sci. 1994 Nov;77(11):3275-86.

安全

• 危害码 (欧洲): T

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