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52-39-1

52-39-1 structure
52-39-1 structure
  • Name: aldosterone
  • Chemical Name: aldosterone
  • CAS Number: 52-39-1
  • Molecular Formula: C21H28O5
  • Molecular Weight: 360.444
  • Catalog: Chemical reagent Organic reagent Aromatic acid
  • Create Date: 2018-02-04 08:00:00
  • Modify Date: 2025-08-20 12:32:32
  • Aldosterone is the primary mineralocorticoid. Aldosterone is a steroid hormone, and it is synthesized and secreted in response to renin-angiotensin system activation (RAS) or high dietary potassium by the zona glomerulosa (ZG) of the adrenal cortex. Aldosterone activity is dependent by the binding and activation of the cytoplasmic/nuclear mineralocorticoid receptor (MR) at cellular level[1][2].
Name aldosterone
Synonyms 11β,21-Dihydroxy-3,20-dioxo-pregn-4-en-18-al
Pregn-4-en-18-al, 11,21-dihydroxy-3,20-dioxo-, (11β)-
(11β)-11,21-dihydroxy-3,20-dioxo-Pregn-4-en-18-al
Aldocorten
Aldocortene
(11b)-11,21-dihydroxy-3,20-dioxo-pregn-4-en-18-al
11-β,21-Dihydroxy-3,20-dioxopregn-4-en-18-al
Aldocortin
MFCD00051136
Aldosterone
(11β)-11,21-Dihydroxy-3,20-dioxopregn-4-en-18-al
d-Aldosterone
18-Oxocorticosterone
(11b)-11,21-Dihydroxy-3,20-dioxopregn-4-en-18-al
18-Formyl-11b,21-dihydroxy-4-pregnene-3,20-dione
11b,21-dihydroxy-3,20-dioxo-pregn-4-en-18-al
11β,21-Dihydroxypregn-4-ene-3,18,20-trione
(8S,9S,10R,11S,13R,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10-methyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthrene-13-carbaldehyde
Reichstein X
Elektrocortin
4-pregnen-11,21-diol-3,20-dione-18-al
EINECS 200-139-9
Electrocortin
Description Aldosterone is the primary mineralocorticoid. Aldosterone is a steroid hormone, and it is synthesized and secreted in response to renin-angiotensin system activation (RAS) or high dietary potassium by the zona glomerulosa (ZG) of the adrenal cortex. Aldosterone activity is dependent by the binding and activation of the cytoplasmic/nuclear mineralocorticoid receptor (MR) at cellular level[1][2].
Related Catalog
Target

Human Endogenous Metabolite

In Vitro Aldosterone (1-1000 nM; 24 hours) inhibits interleukin-1β-stimulated nitrite production by vascular smooth muscle cells in a dose-dependent manner[3].
In Vivo Aldosterone (1 mg/Kg+1% NaCl; i.h.; once daily for 3 weeks) significantly increases systolic blood pressure (SBP), diastolic blood pressure (DBP), left ventricular systolic pressure (LVSP) and left ventricular end-diastolic pressure (LVEDP)[4]. Aldosterone (0.72 mg/kg/day; 14 days) causes a small increase ( 14 mmHg) in blood pressure in male mice[5]. Animal Model: Forty male Wistar rats[4] Dosage: 1 mg/Kg (+1% NaCl) Administration: i.h.; once daily for 3 weeks Result: Systolic blood pressure (SBP), diastolic blood pressure (DBP), left ventricular systolic pressure (LVSP) and left ventricular end-diastolic pressure (LVEDP) were significantly higher in aldosterone-salt-treated animals.
References

[1]. Nanba K, et al. Aging and Adrenal Aldosterone Production. Hypertension. 2018 Feb;71(2):218-223.

[2]. Cannavo A, et al. Aldosterone and Mineralocorticoid Receptor System in Cardiovascular Physiology and Pathophysiology. Oxid Med Cell Longev. 2018 Sep 19;2018:1204598.

[3]. Ikeda U, et al. Aldosterone inhibits nitric oxide synthesis in rat vascular smooth muscle cells induced by interleukin-1 beta. Eur J Pharmacol. 1995 Jul 18;290(2):69-73.

[4]. Martín-Fernández B, et al. Beneficial effects of proanthocyanidins in the cardiac alterations induced by aldosterone in ratheart through mineralocorticoid receptor blockade. PLoS One. 2014 Oct 29;9(10):e111104.

[5]. Dinh QN, et al. Aldosterone-induced oxidative stress and inflammation in the brain are mediated by the endothelial cell mineralocorticoid receptor. Brain Res. 2016 Apr 15;1637:146-153.
Density 1.3±0.1 g/cm3
Boiling Point 568.1±50.0 °C at 760 mmHg
Melting Point 170-172ºC
Molecular Formula C21H28O5
Molecular Weight 360.444
Flash Point 311.4±26.6 °C
Exact Mass 360.193665
PSA 91.67000
LogP 0.73
Vapour Pressure 0.0±3.5 mmHg at 25°C
Index of Refraction 1.586

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TU4523000
CHEMICAL NAME :
Pregn-4-en-18-al, 11,21-dihydroxy-3,20-dioxo-, (11-beta)-
CAS REGISTRY NUMBER :
52-39-1
BEILSTEIN REFERENCE NO. :
3224996
LAST UPDATED :
199701
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C21-H28-O5
MOLECULAR WEIGHT :
360.49
WISWESSER LINE NOTATION :
L E5 B666 OV CU MUTJ A1 E1 FV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
DNA damage

MUTATION DATA

TEST SYSTEM :
Rodent - rat
DOSE/DURATION :
23 mg/kg
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 141,14,1972 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3853 No. of Facilities: 46 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 279 (estimated) No. of Female Employees: 46 (estimated)
Symbol GHS02 GHS07
GHS02, GHS07
Signal Word Danger
Hazard Statements H225-H302 + H312 + H332-H319
Precautionary Statements P210-P280-P305 + P351 + P338
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi
Risk Phrases R36/37/38
Safety Phrases 22-24/25-36-26
RIDADR UN 1648 3 / PGII
WGK Germany 3
RTECS TU4523000
HS Code 29372900
124537-57-1 structure

124537-57-1

~%

52-39-1 structure

52-39-1

Literature: Helvetica Chimica Acta, , vol. 38, p. 1423,1436 Experientia, , vol. 12, p. 50
297-91-6 structure

297-91-6

~%

52-39-1 structure

52-39-1

Literature: Helvetica Chimica Acta, , vol. 38, p. 1423,1436
2507-89-3 structure

2507-89-3

~%

52-39-1 structure

52-39-1

Literature: Helvetica Chimica Acta, , vol. 38, p. 1423,1436
3329-80-4 structure

3329-80-4

~%

52-39-1 structure

52-39-1

Literature: Helvetica Chimica Acta, , vol. 38, p. 1423,1436
86698-82-0 structure

86698-82-0

~%

52-39-1 structure

52-39-1

Literature: Helvetica Chimica Acta, , vol. 38, p. 1423,1436
145-13-1 structure

145-13-1

~%

50-22-6 structure

50-22-6

52-39-1 structure

52-39-1

10385-97-4 structure

10385-97-4

Literature: Steroids, , vol. 36, # 5 p. 601 - 609
HS Code 29372900
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