aldosterone

Modify Date: 2024-01-02 22:16:31

aldosterone structure	Common Name	aldosterone
	CAS Number	52-39-1	Molecular Weight	360.444
	Density	1.3±0.1 g/cm3	Boiling Point	568.1±50.0 °C at 760 mmHg
	Molecular Formula	C₂₁H₂₈O₅	Melting Point	170-172ºC
	MSDS	Chinese USA	Flash Point	311.4±26.6 °C
	Symbol	GHS02, GHS07	Signal Word	Danger

Use of aldosterone

Aldosterone is the primary mineralocorticoid. Aldosterone is a steroid hormone, and it is synthesized and secreted in response to renin-angiotensin system activation (RAS) or high dietary potassium by the zona glomerulosa (ZG) of the adrenal cortex. Aldosterone activity is dependent by the binding and activation of the cytoplasmic/nuclear mineralocorticoid receptor (MR) at cellular level[1][2].

Name	aldosterone
Synonym	More Synonyms

Description	Aldosterone is the primary mineralocorticoid. Aldosterone is a steroid hormone, and it is synthesized and secreted in response to renin-angiotensin system activation (RAS) or high dietary potassium by the zona glomerulosa (ZG) of the adrenal cortex. Aldosterone activity is dependent by the binding and activation of the cytoplasmic/nuclear mineralocorticoid receptor (MR) at cellular level[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease
Target	Human Endogenous Metabolite
In Vitro	Aldosterone (1-1000 nM; 24 hours) inhibits interleukin-1β-stimulated nitrite production by vascular smooth muscle cells in a dose-dependent manner[3].
In Vivo	Aldosterone (1 mg/Kg+1% NaCl; i.h.; once daily for 3 weeks) significantly increases systolic blood pressure (SBP), diastolic blood pressure (DBP), left ventricular systolic pressure (LVSP) and left ventricular end-diastolic pressure (LVEDP)[4]. Aldosterone (0.72 mg/kg/day; 14 days) causes a small increase ( 14 mmHg) in blood pressure in male mice[5]. Animal Model: Forty male Wistar rats[4] Dosage: 1 mg/Kg (+1% NaCl) Administration: i.h.; once daily for 3 weeks Result: Systolic blood pressure (SBP), diastolic blood pressure (DBP), left ventricular systolic pressure (LVSP) and left ventricular end-diastolic pressure (LVEDP) were significantly higher in aldosterone-salt-treated animals.
References	[1]. Nanba K, et al. Aging and Adrenal Aldosterone Production. Hypertension. 2018 Feb;71(2):218-223. [2]. Cannavo A, et al. Aldosterone and Mineralocorticoid Receptor System in Cardiovascular Physiology and Pathophysiology. Oxid Med Cell Longev. 2018 Sep 19;2018:1204598. [3]. Ikeda U, et al. Aldosterone inhibits nitric oxide synthesis in rat vascular smooth muscle cells induced by interleukin-1 beta. Eur J Pharmacol. 1995 Jul 18;290(2):69-73. [4]. Martín-Fernández B, et al. Beneficial effects of proanthocyanidins in the cardiac alterations induced by aldosterone in ratheart through mineralocorticoid receptor blockade. PLoS One. 2014 Oct 29;9(10):e111104. [5]. Dinh QN, et al. Aldosterone-induced oxidative stress and inflammation in the brain are mediated by the endothelial cell mineralocorticoid receptor. Brain Res. 2016 Apr 15;1637:146-153.

Density	1.3±0.1 g/cm3
Boiling Point	568.1±50.0 °C at 760 mmHg
Melting Point	170-172ºC
Molecular Formula	C₂₁H₂₈O₅
Molecular Weight	360.444
Flash Point	311.4±26.6 °C
Exact Mass	360.193665
PSA	91.67000
LogP	0.73
Vapour Pressure	0.0±3.5 mmHg at 25°C
Index of Refraction	1.586

aldosterone MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TU4523000

CHEMICAL NAME :: Pregn-4-en-18-al, 11,21-dihydroxy-3,20-dioxo-, (11-beta)-

CAS REGISTRY NUMBER :: 52-39-1

BEILSTEIN REFERENCE NO. :: 3224996

LAST UPDATED :: 199701

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C21-H28-O5

MOLECULAR WEIGHT :: 360.49

WISWESSER LINE NOTATION :: L E5 B666 OV CU MUTJ A1 E1 FV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: DNA damage

MUTATION DATA

TEST SYSTEM :: Rodent - rat

DOSE/DURATION :: 23 mg/kg

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 141,14,1972 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3853 No. of Facilities: 46 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 279 (estimated) No. of Female Employees: 46 (estimated)

Symbol	GHS02, GHS07
Signal Word	Danger
Hazard Statements	H225-H302 + H312 + H332-H319
Precautionary Statements	P210-P280-P305 + P351 + P338
Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
Risk Phrases	R36/37/38
Safety Phrases	22-24/25-36-26
RIDADR	UN 1648 3 / PGII
WGK Germany	3
RTECS	TU4523000
HS Code	29372900

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Pregnenolone

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Precursor 6
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DownStream 1
CAS#:76959-24-5 1-Dehydroaldosterone

HS Code	29372900

Cistrome of the aldosterone-activated mineralocorticoid receptor in human renal cells.

FASEB J. 29 , 3977-89, (2015)

Aldosterone exerts its effects mainly by activating the mineralocorticoid receptor (MR), a transcription factor that regulates gene expression through complex and dynamic interactions with coregulator...

Finerenone Impedes Aldosterone-dependent Nuclear Import of the Mineralocorticoid Receptor and Prevents Genomic Recruitment of Steroid Receptor Coactivator-1.

J. Biol. Chem. 290 , 21876-89, (2015)

Aldosterone regulates sodium homeostasis by activating the mineralocorticoid receptor (MR), a member of the nuclear receptor superfamily. Hyperaldosteronism leads todeleterious effects on the kidney, ...

Sodium homeostasis is preserved in a global 11β-hydroxysteroid dehydrogenase type 1 knockout mouse model.

Exp. Physiol. 100 , 1362-78, (2015)

What is the central question of this study? Glucocorticoids act in the kidney to promote salt and water retention. Renal 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1), by increasing local concentr...

11β,21-Dihydroxy-3,20-dioxo-pregn-4-en-18-al

Pregn-4-en-18-al, 11,21-dihydroxy-3,20-dioxo-, (11β)-

(11β)-11,21-dihydroxy-3,20-dioxo-Pregn-4-en-18-al

Aldocorten

Aldocortene

(11b)-11,21-dihydroxy-3,20-dioxo-pregn-4-en-18-al

11-β,21-Dihydroxy-3,20-dioxopregn-4-en-18-al

Aldocortin

MFCD00051136

Aldosterone

(11β)-11,21-Dihydroxy-3,20-dioxopregn-4-en-18-al

d-Aldosterone

18-Oxocorticosterone

(11b)-11,21-Dihydroxy-3,20-dioxopregn-4-en-18-al

18-Formyl-11b,21-dihydroxy-4-pregnene-3,20-dione

11b,21-dihydroxy-3,20-dioxo-pregn-4-en-18-al

11β,21-Dihydroxypregn-4-ene-3,18,20-trione

(8S,9S,10R,11S,13R,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10-methyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthrene-13-carbaldehyde

Reichstein X

Elektrocortin

4-pregnen-11,21-diol-3,20-dione-18-al

EINECS 200-139-9

Electrocortin

DC Chemicals Limited
China
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Purity: 98.0%
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Dayang Chem (Hangzhou) Co., Ltd.
China
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Zhejiang Hangyu API Co., Ltd
China
Product Name: ALDOSTERONE
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
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aldosterone

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