87051-43-2

87051-43-2 structure

Name: Ritanserin
Chemical Name: ritanserin
CAS Number: 87051-43-2
Molecular Formula: C₂₇H₂₅F₂N₃OS
Molecular Weight: 477.56900
Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
Create Date: 2018-05-15 08:00:00
Modify Date: 2025-08-21 18:08:47
Ritanserin (R 55667) is a highly potent, relatively selective, orally active, long acting antagonist of 5-HT2 receptor, with an IC50 of 0.9 nM, less active on Histamine H1, Dopamine D2, Adrenergic α1, Adrenergic α2 receptors[1].

Name	ritanserin
Synonyms	6-[2-[4-[bis(4-fluorophenyl)methylidene]piperidin-1-yl]ethyl]-7-methyl-[1,3]thiazolo[3,2-a]pyrimidin-5-one Ritanserinum Ritanserina Ritanserine risperidone Tiserton

Description	Ritanserin (R 55667) is a highly potent, relatively selective, orally active, long acting antagonist of 5-HT2 receptor, with an IC50 of 0.9 nM, less active on Histamine H1, Dopamine D2, Adrenergic α1, Adrenergic α2 receptors[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
Target	IC50: 0.9 nM (5-HT2 receptor), 35 nM (H1 receptor), 70 nM (D2 receptor), 97 nM (α1 receptor), 150 nM (α2 receptor)[1]
In Vitro	Ritanserin (R 55667) is a highly potent, relatively selective, long acting antagonist of 5-HT2 receptor, with an IC50 of 0.9 nM, less active on Histamine-H1 (IC50, 35 nM), Dopamine-D2 (IC50, 70 nM), Adrenergic-α1 (IC50, 97 nM), Adrenergic-α2 receptor (IC50, 150 nM)[1].
References	[1]. Leysen JE, et al. Receptor-binding properties in vitro and in vivo of ritanserin: A very potent and long acting serotonin-S2 antagonist. Mol Pharmacol. 1985 Jun;27(6):600-11.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
RIDADR	NONH for all modes of transport