137361-05-8

137361-05-8 structure

Name: Nω-Propyl-L-arginine
Chemical Name: (2S)-2-amino-5-[(N'-propylcarbamimidoyl)amino]pentanoic acid
CAS Number: 137361-05-8
Molecular Formula: C₉H₂₀N₄O₂
Molecular Weight: 216.281
Catalog: Signaling Pathways Immunology/Inflammation NO Synthase
Create Date: 2018-07-10 17:26:40
Modify Date: 2024-01-08 19:43:27
Nω-Propyl-L-arginine (N-omega-Propyl-L-arginine) is a potent, competitive, and highly selective inhibitor of neuronal nitric oxide synthase (nNOS), with a Ki of 57 nM. Nω-Propyl-L-arginine displays a 149-fold selectivity for nNOS over endothelial NOS (eNOS)[1][2].

Name	(2S)-2-amino-5-[(N'-propylcarbamimidoyl)amino]pentanoic acid
Synonyms	N-(N'-Propylcarbamimidoyl)-L-ornithine 3AR Tocris-1200 L-Ornithine, N-[(E)-amino(propylimino)methyl]- MFCD01320455

Description	Nω-Propyl-L-arginine (N-omega-Propyl-L-arginine) is a potent, competitive, and highly selective inhibitor of neuronal nitric oxide synthase (nNOS), with a Ki of 57 nM. Nω-Propyl-L-arginine displays a 149-fold selectivity for nNOS over endothelial NOS (eNOS)[1][2].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> NO Synthase Research Areas >> Neurological Disease
In Vivo	Nω-Propyl-L-arginine (N-omega-Propyl-L-arginine) (20 mg/kg; i.p.) blocks both phencyclidine-induced disruption of prepulse inhibition and phencyclidine-induced stimulation of locomotor activity[2]. Animal Model: Male NMRI mice (30-40 g) (phencyclidine-induced stimulation)[2] Dosage: 20 mg/kg Administration: I.p. Result: Markedly reduced the phencyclidineinduced disruption of prepulse inhibition and significantly reduced the phencyclidine-induced stimulation of locomotor activity.
References	[1]. Zhang HQ, et al. Potent and selective inhibition of neuronal nitric oxide synthase by N omega-propyl-L-arginine. J Med Chem. 1997 Nov 21;40(24):3869-70. [2]. Klamer D, et al. The neuronal selective nitric oxide synthase inhibitor, Nomega-propyl-L-arginine, blocks the effects of phencyclidine on prepulse inhibition and locomotor activity in mice. Eur J Pharmacol. 2004 Oct 25;503(1-3):103-7.

Hazard Codes	C,O
Risk Phrases	R8:Contact with combustible material may cause fire. R34:Causes burns.
Safety Phrases	S26-S27-S36/37/39-S45-S17
RIDADR	UN 3264 8/PG 2
WGK Germany	3
Packaging Group	II
Hazard Class	5.1
HS Code	2925290090

HS Code	2925290090
Summary	2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%