128007-31-8

128007-31-8 structure

Name: Arvanil
Chemical Name: Arvanil,N-[(4-Hydroxy-3-methoxyphenyl)methyl]-5Z,8Z,11Z,14Z-eicosatetraenamide
CAS Number: 128007-31-8
Molecular Formula: C₂₈H₄₁NO₃
Molecular Weight: 439.63
Catalog: Signaling Pathways GPCR/G Protein Cannabinoid Receptor
Create Date: 2018-12-29 17:03:20
Modify Date: 2025-08-29 17:16:46
Arvanil is a ligand for vanilloid receptor 1 (VR1) and cannabinoid 1 (CB1). Arvanil can inhibit spasticity, as a potent neuroprotectant[1].

Name	Arvanil,N-[(4-Hydroxy-3-methoxyphenyl)methyl]-5Z,8Z,11Z,14Z-eicosatetraenamide
Synonyms	(5Z,8Z,11Z,14Z)-N-(4-Hydroxy-3-methoxybenzyl)-5,8,11,14-icosatetraenamide N-vanillyl-5Z,8Z,11Z,14Z-eicosatetraenamide 5,8,11,14-Eicosatetraenamide, N-[(4-hydroxy-3-methoxyphenyl)methyl]-, (5Z,8Z,11Z,14Z)- ARVANIL Picrotoxin (5Z,8Z,11Z,14Z)-N-(4-Hydroxy-3-methoxybenzyl)icosa-5,8,11,14-tetraenamide N-arachidonoylvanillamine N-VANILLYLARACHIDONAMIDE MFCD01752675

Description	Arvanil is a ligand for vanilloid receptor 1 (VR1) and cannabinoid 1 (CB1). Arvanil can inhibit spasticity, as a potent neuroprotectant[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Cannabinoid Receptor
Target	VR1, CB1[1]
References	[1]. Veldhuis WB, et al. Neuroprotection by the endogenous cannabinoid anandamide and arvanil against in vivo excitotoxicity in the rat: role of vanilloid receptors and lipoxygenases. J Neurosci. 2003;23(10):4127-4133.

Density	1.0±0.1 g/cm3
Boiling Point	619.4±55.0 °C at 760 mmHg
Molecular Formula	C₂₈H₄₁NO₃
Molecular Weight	439.63
Flash Point	328.4±31.5 °C
Exact Mass	439.308655
PSA	58.56000
LogP	7.00
Vapour Pressure	0.0±1.9 mmHg at 25°C
Index of Refraction	1.533
Storage condition	-20°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: JX3845000

CHEMICAL NAME :: 5,8,11,14-Eicosatetraenamide, N-((4-hydroxy-3-methoxyphenyl)methyl)-, (all-Z)-

CAS REGISTRY NUMBER :: 128007-31-8

LAST UPDATED :: 199509

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C28-H41-N-O3

MOLECULAR WEIGHT :: 439.70

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 36,2595,1993

Symbol	GHS02, GHS07
Signal Word	Danger
Hazard Statements	H225-H319
Precautionary Statements	P210-P305 + P351 + P338-P370 + P378-P403 + P235
RIDADR	UN1170 - class 3 - PG 2 - Ethanol

506-32-1

7149-10-2

~96%

128007-31-8

Literature: Appendino, Giovanni; Minassi, Alberto; Morello, Aniello Schiano; De Petrocellis, Luciano; Di Marzo, Vincenzo Journal of Medicinal Chemistry, 2002 , vol. 45, # 17 p. 3739 - 3745

506-32-1

128007-31-8

Literature: Janusz, John M.; Buckwalter, Brian L.; Young, Patricia A.; LaHann, Thomas R.; Farmer, Ralph W.; et al. Journal of Medicinal Chemistry, 1993 , vol. 36, # 18 p. 2595 - 2604

1196-92-5

57303-04-5

~33%

128007-31-8

Literature: Janusz, John M.; Buckwalter, Brian L.; Young, Patricia A.; LaHann, Thomas R.; Farmer, Ralph W.; et al. Journal of Medicinal Chemistry, 1993 , vol. 36, # 18 p. 2595 - 2604

Precursor 4
506-32-1 7149-10-2 1196-92-5 57303-04-5
DownStream 0

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