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1222781-70-5

1222781-70-5 structure
1222781-70-5 structure

Name 1-(4-methoxyphenyl)-N-(naphthalen-1-ylmethyl)methanamine,hydrochloride
Synonyms N-(4-methoxybenzyl)-1-(naphthalen-1-yl)methanamine hydrochloride
ML133 hydrochloride
ML133 HCL
1-Naphthalenemethanamine (N-[(4-methoxyphenyl)methyl]
Description ML133 (hydrochloride) is a selective Kir2 family channels inhibitor, with an IC50 of 1.8 μM at pH 7.4 and 290 nM at pH 8.5[1].
Related Catalog
Target

IC50: 1.8 μM (Kir2 at pH 7.4), 290 nM (Kir2 at pH 8.5)[1].

References

[1]. Wang HR, et al. Selective inhibition of the K(ir)2 family of inward rectifier potassium channels by a small molecule probe: the discovery, SAR, and pharmacological characterization of ML133. ACS Chem Biol. 2011 Aug 19;6(8):845-56.

Molecular Formula C19H20ClNO
Molecular Weight 313.82100
Exact Mass 313.12300
PSA 21.26000
LogP 5.33110
Appearance white to tan
Storage condition 2-8°C
Water Solubility DMSO: ≥10mg/mL
Symbol GHS05 GHS07 GHS09
GHS05, GHS07, GHS09
Signal Word Danger
Hazard Statements H302-H315-H318-H335-H400
Precautionary Statements P261-P273-P280-P305 + P351 + P338
Hazard Codes Xn,N
Risk Phrases 22-37/38-41-50/53
Safety Phrases 26-39-60-61
RIDADR UN 3077 9 / PGIII
HS Code 2922299090
HS Code 2922299090
Summary 2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%