142326-59-8
142326-59-8 structure
- Name: L 701324
- Chemical Name: 7-chloro-4-hydroxy-3-(3-phenoxyphenyl)-1H-quinolin-2-one
- CAS Number: 142326-59-8
- Molecular Formula: C21H14ClNO3
- Molecular Weight: 363.794
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel iGluR
- Create Date: 2018-12-27 20:43:25
- Modify Date: 2025-08-26 21:28:06
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L-701324 is an orally active and long acting anticonvulsant with high affinity and selectivity for the glycine site on the NMDA receptor.Target: NMDA ReceptorL-701324 is a potent, active anticonvulsant with a reduced propensity to activate mesolimbic dopaminergic systems in rodents. L-701324 exhibits a beneficial action in the animal model of parkinsonian rigidity, but not that of parkinsonian akinesia. L-701324 (2.5-40 mg/kg, i.p.) dose-dependently decreased the muscle tone enhanced by haloperidol (1-5 mg/kg, i.p.).
| Name | 7-chloro-4-hydroxy-3-(3-phenoxyphenyl)-1H-quinolin-2-one |
|---|---|
| Synonyms |
7-chloro-3-(3-phenoxyphenyl)quinoline-2,4-diol
Sulprostone 2(1H)-Quinolinone, 7-chloro-4-hydroxy-3-(3-phenoxyphenyl)- 2,4-quinolinediol, 7-chloro-3-(3-phenoxyphenyl)- 7-Chloro-4-hydroxy-3-(3-phenoxyphenyl)-2(1H)-quinolinone 7-Chloro-4-hydroxy-3-(3-phenoxyphenyl)quinolin-2(1H)-one L-701,324 L-701324 |
| Description | L-701324 is an orally active and long acting anticonvulsant with high affinity and selectivity for the glycine site on the NMDA receptor.Target: NMDA ReceptorL-701324 is a potent, active anticonvulsant with a reduced propensity to activate mesolimbic dopaminergic systems in rodents. L-701324 exhibits a beneficial action in the animal model of parkinsonian rigidity, but not that of parkinsonian akinesia. L-701324 (2.5-40 mg/kg, i.p.) dose-dependently decreased the muscle tone enhanced by haloperidol (1-5 mg/kg, i.p.). |
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| Related Catalog | |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 584.7±50.0 °C at 760 mmHg |
| Molecular Formula | C21H14ClNO3 |
| Molecular Weight | 363.794 |
| Flash Point | 307.4±30.1 °C |
| Exact Mass | 363.066223 |
| PSA | 62.32000 |
| LogP | 5.50 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.680 |
| Storage condition | 2-8℃ |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26 |
| RIDADR | NONH for all modes of transport |