89889-51-0
89889-51-0 structure
- Name: Biotin-C5-amino-C5-amino
- Chemical Name: 6-[6-[5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]hexanoylamino]hexanoic acid
- CAS Number: 89889-51-0
- Molecular Formula: C22H38N4O5S
- Molecular Weight: 470.62600
- Catalog: Signaling Pathways PROTAC PROTAC Linker
- Create Date: 2017-03-22 00:56:19
- Modify Date: 2025-08-21 11:27:18
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Biotin-C5-amino-C5-amino is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
| Name | 6-[6-[5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]hexanoylamino]hexanoic acid |
|---|---|
| Synonyms |
D-biotinylaminohexanoylaminohexanoic acid
D-biotin-Acp-Acp-OH N-Biotinylcaproylaminocaproic Acid |
| Description | Biotin-C5-amino-C5-amino is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
|---|---|
| Related Catalog | |
| Target |
Alkyl-Chain |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
| References |
| Molecular Formula | C22H38N4O5S |
|---|---|
| Molecular Weight | 470.62600 |
| Exact Mass | 470.25600 |
| PSA | 172.40000 |
| LogP | 3.79940 |
| Storage condition | 2-8°C |
|
~%
89889-51-0 |
| Literature: Plaziuk, Damian; Zakrzewski, Janusz; Salmain, Michele; Blauzi, Andrzej; Rychlik, Blaziej; Strzelczyk, Pawel; Bujacz, Anna; Bujacz, Grzegorz Organometallics, 2013 , vol. 32, # 20 p. 5774 - 5783 |
| Precursor 2 | |
|---|---|
| DownStream 0 | |