- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: Biotin-C5-NHS Ester
- Price: Check
- Purity: 98.0%
- Stocking Period: 10 Day
- Contact: Yang
- Email: sales@echemcloud.com
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: Biotin-C5-NHS Ester
- Price: ￥708.0/25mg ￥5748.0/500mg ￥248.0/5mg ￥1338.0/100mg
- Purity: 98.0%
- Stocking Period: 2 Day
- Contact: Liu jia
- Email: 2130147988@qq.com
- DC Chemicals Limited
- China
- Product Name: NHS-LC-Biotin
- Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: Succinimidyl-6-(biotinamido) hexanoate
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Ms Wang
- Email: enquiry@dycnchem.com
- Shanghai Amole Biotechnology Co., Ltd.
- China
- Product Name: Biotin-C5-NHS Ester
- Price: ￥Inquiry/100mg ￥Inquiry/1g ￥Inquiry/250mg ￥Inquiry/5g
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Xiyao Wang
- Email: 3623107365@qq.com
72040-63-2
72040-63-2 structure
- Name: Biotin-C5-NHS Ester
- Chemical Name: Succinimidyl-6-(biotinamido) Hexanoate
- CAS Number: 72040-63-2
- Molecular Formula: C20H30N4O6S
- Molecular Weight: 454.540
- Catalog: Signaling Pathways PROTAC PROTAC Linker
- Create Date: 2018-12-28 21:16:11
- Modify Date: 2025-08-23 17:11:44
-
Biotin-C5-NHS Ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].
| Name | Succinimidyl-6-(biotinamido) Hexanoate |
|---|---|
| Synonyms |
(2,5-dioxopyrrolidin-1-yl) 6-[5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]hexanoate
N-{6-[(2,5-dioxopyrrolidin-1-yl)oxy]-6-oxohexyl}-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide MFCD00065502 N-{6-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-6-oxohexyl}-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide 1H-Thieno[3,4-d]imidazole-4-pentanamide, N-[6-[(2,5-dioxo-1-pyrrolidinyl)oxy]-6-oxohexyl]hexahydro-2-oxo-, (3aS,4S,6aR)- |
| Description | Biotin-C5-NHS Ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
|---|---|
| Related Catalog | |
| Target |
Alkyl/ether |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Melting Point | 169-171 °C |
| Molecular Formula | C20H30N4O6S |
| Molecular Weight | 454.540 |
| Exact Mass | 454.188599 |
| PSA | 159.21000 |
| LogP | -1.62 |
| Index of Refraction | 1.591 |
| Storage condition | −20°C |
| Stability | Moisture Sensitive |
| Water Solubility | H2O: ≤2 mg/mL with sonication |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
|
~56%
72040-63-2 |
| Literature: Wang, Tzu-Pin; Chiou, Yi-Jang; Chen, Yi; Wang, Eng-Chi; Hwang, Long-Chih; Chen, Bing-Hung; Chen, Yen-Hsu; Ko, Chun-Han Bioconjugate Chemistry, 2010 , vol. 21, # 9 p. 1642 - 1655 |
|
~%
72040-63-2 |
| Literature: Bioconjugate Chemistry, , vol. 21, # 9 p. 1642 - 1655 |
|
~%
72040-63-2 |
| Literature: Bioconjugate Chemistry, , vol. 21, # 9 p. 1642 - 1655 |
|
~%
72040-63-2 |
| Literature: Bioconjugate Chemistry, , vol. 21, # 9 p. 1642 - 1655 |
| Precursor 5 | |
|---|---|
| DownStream 0 | |