5580-20-1
- Name: 4-Thiodeoxyuridine
- Chemical Name: 2(1H)-Pyrimidinone, 1-(2-deoxy-.β.-D-erythro-pentofuranosyl)-3,4-dihydro-4-thioxo
- CAS Number: 5580-20-1
- Molecular Formula: C9H12N2O4S
- Molecular Weight: 244.27
- Catalog: Signaling Pathways Cell Cycle/DNA Damage Nucleoside Antimetabolite/Analog
- Create Date: 2017-02-20 05:30:22
- Modify Date: 2025-08-26 23:43:32
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4-Thio-2’-deoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
| Name | 2(1H)-Pyrimidinone, 1-(2-deoxy-.β.-D-erythro-pentofuranosyl)-3,4-dihydro-4-thioxo |
|---|---|
| Synonyms |
desoxysesbanine
4-thiodeoxyuridine 2'-deoxy-4-thiouridine Deoxythiouridine DEOXYSESBANINE 4-thio-2'-deoxyuridine |
| Description | 4-Thio-2’-deoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. |
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| Related Catalog | |
| References |
| Density | 1.59g/cm3 |
|---|---|
| Melting Point | 169 °C |
| Molecular Formula | C9H12N2O4S |
| Molecular Weight | 244.27 |
| Exact Mass | 244.05200 |
| PSA | 119.57000 |
| Index of Refraction | 1.697 |
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| Literature: Coleman, Robert S.; Kesicki, Edward A. Journal of the American Chemical Society, 1994 , vol. 116, # 26 p. 11636 - 11642 |
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| Literature: Toppin, Charles R.; Pauly, Gary T.; Devanesan, Prabu; Kryak, David; Bobst, Albert M. Helvetica Chimica Acta, 1986 , vol. 69, p. 345 - 349 |
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| Literature: Coleman; Siedlecki Tetrahedron Letters, 1991 , vol. 32, # 26 p. 3033 - 3034 |
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| Literature: Coleman; Siedlecki Tetrahedron Letters, 1991 , vol. 32, # 26 p. 3033 - 3034 |
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| Literature: Coleman; Siedlecki Tetrahedron Letters, 1991 , vol. 32, # 26 p. 3033 - 3034 |
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| Literature: Zhang, Xiaohui; Xu, Yao-Zhong Molecules, 2011 , vol. 16, # 7 p. 5655 - 5664 |
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| Literature: Ruda, Gian Filippo; Nguyen, Corinne; Ziemkowski, Przemyslaw; Felczak, Krzysztof; Kasinathan, Ganasan; Musso-Buendia, Alexander; Sund, Christian; Zhou, Xiao Xiong; Kaiser, Marcel; Ruiz-Perez, Luis M.; Brun, Reto; Kulikowski, Tadeusz; Johansson, Nils Gunnar; Gonzalez-Pacanowska, Dolores; Gilbert, Ian H. ChemMedChem, 2011 , vol. 6, # 2 p. 309 - 320 |
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5580-20-1 |
| Literature: Ruda, Gian Filippo; Nguyen, Corinne; Ziemkowski, Przemyslaw; Felczak, Krzysztof; Kasinathan, Ganasan; Musso-Buendia, Alexander; Sund, Christian; Zhou, Xiao Xiong; Kaiser, Marcel; Ruiz-Perez, Luis M.; Brun, Reto; Kulikowski, Tadeusz; Johansson, Nils Gunnar; Gonzalez-Pacanowska, Dolores; Gilbert, Ian H. ChemMedChem, 2011 , vol. 6, # 2 p. 309 - 320 |
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5580-20-1 |
| Literature: Visser; Elsinga; Vaalburg Journal of Labelled Compounds and Radiopharmaceuticals, 1999 , vol. 42, # SUPPL. 1 p. S614-S616 |
| Precursor 6 | |
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| DownStream 0 | |