2751-68-0

2751-68-0 structure

Name: acetophenazine
Chemical Name: acetophenazine
CAS Number: 2751-68-0
Molecular Formula: C₂₃H₂₉N₃O₂S
Molecular Weight: 411.56000
Catalog: Signaling Pathways GPCR/G Protein Dopamine Receptor
Create Date: 2018-09-29 11:26:33
Modify Date: 2024-01-02 17:08:38
Acetophenazine, a phenothiazine derivative, is an antipsychotic agent. Acetophenazine primarily blocks dopamine D2 receptors in the brain. Acetophenazine can be used for researching psychotic disorders such as schizophrenia and anxious depression[1][2].

Name	acetophenazine
Synonyms	1-(10-{3-[4-(2-hydroxy-ethyl)-piperazino]-propyl}-phenothiazin-2-yl)-ethanone Acetophenazinum [INN-Latin] 1-(10-{3-[4-(2-Hydroxy-aethyl)-piperazino]-propyl}-phenothiazin-2-yl)-aethanon 10-<3-(1-(2-Hydroxy-aethyl)-piperazinyl-(4))-propyl>-2-acetyl-phenothiazin 2-acetyl-10-(-3-[4-(2-hydroxyethyl)-1-piperazinyl]propyl)phenothiazine Acetophenazinum 1-[10-[3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl]phenothiazin-2-yl]ethanone Acetophenazina [INN-Spanish] ACETOPHENAZINE Acephenazinum Tindal 1-(10-{3-[4-(2-hydroxy-ethyl)-piperazin-1-yl]-propyl}-10H-phenothiazin-2-yl)-ethanone Acetophenazine [INN]

Description	Acetophenazine, a phenothiazine derivative, is an antipsychotic agent. Acetophenazine primarily blocks dopamine D2 receptors in the brain. Acetophenazine can be used for researching psychotic disorders such as schizophrenia and anxious depression[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease
Target	D2 Receptor
In Vivo	Acetophenazine (2.4 mg/kg; i.h.; single dosage) significantly prolongs the time lapse from the first fight to submission and the actual fighting time to submission in mice[3]. Animal Model: C57BL mice (10-12 weeks)[3] Dosage: 2.4 mg/kg Administration: i.h.; single dosage Result: Significantly prolonged the time lapse from the first fight to submission and the actual fighting time to submission.
References	[1]. Azam Bazrafshan, et al. Acetophenazine versus chlorpromazine for schizophrenia. Cochrane Database of Systematic Reviews. 2015, Issue 4. [2]. Hollister LE, et al. Acetophenazine and diazepam in anxious depressions. Arch Gen Psychiatry. 1971 Mar;24(3):273-8. [3]. KNIGHT WR, HOLTZ JR, SPROGIS GR. ACETOPHENAZINE AND FIGHTING BEHAVIOR IN MICE. Science. 1963 Aug 30;141(3583):830-1.

Hazard Codes	Xn