Name | 4-hydroxybenzoic acid |
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Synonyms |
4-Hydroxybenzoicacid
Benzoic acid,4-hydroxy PARAHYDROXY BENZOIC ACID MFCD00002547 EINECS 202-804-9 4-HYDROXYBENZOIC ACID FOR SYNTHESIS 4-Hydroxybenzoic acid p-Salicylic acid 4-Hydroxy benzoic acid HYDROXYBENZOIC ACID, P- POLYMER GRADE |p|-Hydroxybenzoic acid 4-Hydroxybenzoesaeure Benzoic acid,p-hydroxy P-HYDROXYBENZOIC ACID, REAGENT PROPYL PARAHYDROXYBENZOATE IMP. A (EP): 4-HYDROXYBENZOIC ACID, CRM STANDARD ACETYLSALICYLIC ACID IMPURITY A (ASPIRIN IMPURITY A) 1-Naphthyl phsophoric acid sodium salt 4-Carboxyphenol p-Hydroxybenzoic acid para-Hydroxybenzoic acid 4-hydroxy-benzoic acid papa-hydroxy-benzoic acid p-carboxyphenol |
Description | 4-Hydroxybenzoic acid, a phenolic derivative of benzoic acid, could inhibit most gram-positive and some gram-negative bacteria, with an IC50 of 160 μg/mL. |
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Related Catalog | |
Target |
Human Endogenous Metabolite Bacteria:160 μg/mL (IC50) |
In Vitro | Most of the gram-positive and some gram-negative bacteria are sensitive to trans 4-Hydroxycinnamic acid (4-HBA) and 4-Hydroxybenzoic acid at IC50 concentrations of 100-170 and 160 μg/mL, respectively. The antimicrobial activities of 4-Hydroxycinnamic acid and t4-HCA against 11 food pathogenic bacteria, 6 plant pathogenic bacteria, 2 yeasts and 15 plant pathogenic fungi are tested by the paper disc method. These compounds inhibit the growth of most of the bacteria and yeasts at concentrations of 200-400 μg. However, the inhibition is more effective against most of the gram-positive bacteria. When tested by the paper disc method, 4-Hydroxycinnamic acid has stronger antimicrobial activity than t4-HCA against S. aureus, L. mesenteroides, S. cerevisiae and C. albicans at a concentration of 50 μg. However, no inhibitory effect against fungi was observed at concentrations even up to 1000 μg[1]. |
References |
Density | 1.4±0.1 g/cm3 |
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Boiling Point | 336.2±25.0 °C at 760 mmHg |
Melting Point | 213-217 °C(lit.) |
Molecular Formula | C7H6O3 |
Molecular Weight | 138.121 |
Flash Point | 171.3±19.7 °C |
Exact Mass | 138.031693 |
PSA | 57.53000 |
LogP | 1.42 |
Vapour Pressure | 0.0±0.8 mmHg at 25°C |
Index of Refraction | 1.616 |
Storage condition | Refrigerator |
Water Solubility | 5 g/L (20 ºC) |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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Symbol |
GHS07 |
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Signal Word | Warning |
Hazard Statements | H315-H319-H335 |
Precautionary Statements | P261-P305 + P351 + P338 |
Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
Hazard Codes | Xi:Irritant |
Risk Phrases | R36/37/38 |
Safety Phrases | S26-S37/39-S36 |
RIDADR | NONH for all modes of transport |
WGK Germany | 1 |
RTECS | DH1925000 |
HS Code | 2916399090 |
Precursor 10 | |
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DownStream 10 | |
HS Code | 2918290000 |
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Summary | HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0% |