Name | N-TERT-BUTYL-α-PHENYLNITRONE |
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Synonyms |
N-tert-Butyl-alpha-phenylnitrone
phenyl t-butyl nitrone N-Benzylidene-tert-butylamine N-oxide,PBN,Phenyl N-t-butylnitrone N-tert-Butyl-α-phenylnitrone Styryl phenyl sulfone 2-Phenylethenyl phenyl sulfone MFCD00008799 EINECS 222-168-6 N-Benzylidene-N-(2-methyl-2-propanyl)amine oxide N-benzylidene-tert-butylamine N-oxide n-tert-butyl-n-[(e)-phenylmethylene]amine oxide N-benzylidene-t-butylamine N-oxide PHENYL TRANS-STYRYL SULFONE 99 Azane, (1,1-dimethylethyl)(phenylmethylene)-, oxide |
Description | N-tert-Butyl-α-phenylnitrone is a nitrone-based free radical scavenger that forms nitroxide spin adducts. N-tert-Butyl-α-phenylnitrone inhibits COX2 catalytic activity. N-tert-Butyl-α-phenylnitrone has potent ROS scavenging, anti-inflammatory, neuroprotective, anti-aging and anti-diabetic activities, and can penetrate the blood-brain barrier[1][2][3][4]. |
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Related Catalog | |
Target |
COX-2 Reactive oxygen species (ROS) |
In Vitro | N-tert-Butyl-α-phenylnitrone (PBN) (25-100 µM) treatment leads to a significant decrease in 2,2'-azobis (2-amidinopropane) dihydrochloride (AAPH)-induced intracellular ROS accumulation. N-tert-Butyl-α-phenylnitrone also attenuates AAPH-induced cytotoxicity, matrix degradation, and apoptosis. N-tert-Butyl-α-phenylnitrone suppresses AAPH-induced activation of ERK/MAPK pathway. N-tert-Butyl-α-phenylnitrone has the potenial for intervertebral disc degeneration (IDD) research[1]. |
In Vivo | N-tert-Butyl-α-phenylnitrone (PBN; 100 mg/kg; intraperitoneal injection; twice a day; C57Bl/6 mice) treatment not only abolishes the LPS-induced lipid peroxidation, nitrotyrosine residue levels, and GSH depletion, but also decreases the incidence of external malformations[2]. Animal Model: C57Bl/6 mice induced by lipopolysaccharide (LPS)[2] Dosage: 100 mg/kg Administration: Intraperitoneal injection; twice a day (on gestational day 8) Result: Abolished LPS-induced lipid peroxidation, nitrotyrosine residues, and GSH depletion. |
References |
Density | 1.0±0.1 g/cm3 |
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Boiling Point | 283.3±23.0 °C at 760 mmHg |
Melting Point | 71-75ºC |
Molecular Formula | C11H15NO |
Molecular Weight | 177.243 |
Flash Point | 118.5±15.4 °C |
Exact Mass | 177.115356 |
PSA | 28.75000 |
LogP | 1.25 |
Appearance | powder | white |
Vapour Pressure | 0.0±0.6 mmHg at 25°C |
Index of Refraction | 1.552 |
Storage condition | 2-8°C |
Water Solubility | DMSO: soluble |
Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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Hazard Codes | Xn |
Safety Phrases | S24/25 |
RIDADR | NONH for all modes of transport |
WGK Germany | 3 |
RTECS | TX1760000 |
HS Code | 2925290090 |
Precursor 10 | |
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DownStream 8 | |
HS Code | 2925290090 |
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Summary | 2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0% |