n-tert-butyl-n-[(e)-phenylmethylene]amine oxide

Modify Date: 2024-01-02 18:27:15

n-tert-butyl-n-[(e)-phenylmethylene]amine oxide structure	Common Name	n-tert-butyl-n-[(e)-phenylmethylene]amine oxide
	CAS Number	3376-24-7	Molecular Weight	177.243
	Density	1.0±0.1 g/cm3	Boiling Point	283.3±23.0 °C at 760 mmHg
	Molecular Formula	C₁₁H₁₅NO	Melting Point	71-75ºC
	MSDS	Chinese USA	Flash Point	118.5±15.4 °C

Use of n-tert-butyl-n-[(e)-phenylmethylene]amine oxide

N-tert-Butyl-α-phenylnitrone is a nitrone-based free radical scavenger that forms nitroxide spin adducts. N-tert-Butyl-α-phenylnitrone inhibits COX2 catalytic activity. N-tert-Butyl-α-phenylnitrone has potent ROS scavenging, anti-inflammatory, neuroprotective, anti-aging and anti-diabetic activities, and can penetrate the blood-brain barrier[1][2][3][4].

Name	N-TERT-BUTYL-α-PHENYLNITRONE
Synonym	More Synonyms

Description	N-tert-Butyl-α-phenylnitrone is a nitrone-based free radical scavenger that forms nitroxide spin adducts. N-tert-Butyl-α-phenylnitrone inhibits COX2 catalytic activity. N-tert-Butyl-α-phenylnitrone has potent ROS scavenging, anti-inflammatory, neuroprotective, anti-aging and anti-diabetic activities, and can penetrate the blood-brain barrier[1][2][3][4].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> COX Research Areas >> Metabolic Disease Research Areas >> Neurological Disease
Target	COX-2 Reactive oxygen species (ROS)
In Vitro	N-tert-Butyl-α-phenylnitrone (PBN) (25-100 µM) treatment leads to a significant decrease in 2,2'-azobis (2-amidinopropane) dihydrochloride (AAPH)-induced intracellular ROS accumulation. N-tert-Butyl-α-phenylnitrone also attenuates AAPH-induced cytotoxicity, matrix degradation, and apoptosis. N-tert-Butyl-α-phenylnitrone suppresses AAPH-induced activation of ERK/MAPK pathway. N-tert-Butyl-α-phenylnitrone has the potenial for intervertebral disc degeneration (IDD) research[1].
In Vivo	N-tert-Butyl-α-phenylnitrone (PBN; 100 mg/kg; intraperitoneal injection; twice a day; C57Bl/6 mice) treatment not only abolishes the LPS-induced lipid peroxidation, nitrotyrosine residue levels, and GSH depletion, but also decreases the incidence of external malformations[2]. Animal Model: C57Bl/6 mice induced by lipopolysaccharide (LPS)[2] Dosage: 100 mg/kg Administration: Intraperitoneal injection; twice a day (on gestational day 8) Result: Abolished LPS-induced lipid peroxidation, nitrotyrosine residues, and GSH depletion.
References	[1]. Zhenggang Zhou, et al. PBN Protects NP Cells From AAPH-induced Degenerative Changes by Inhibiting the ERK1/2 Pathway. Connect Tissue Res. 2020 Mar 30;1-10. [2]. Lei Zhao, et al. Reactive Oxygen Species Contribute to Lipopolysaccharide-Induced Teratogenesis in Mice. Toxicol Sci. 2008 May;103(1):149-57. [3]. Y Kotake, et al. Inhibition of NF-kappaB, iNOS mRNA, COX2 mRNA, and COX Catalytic Activity by phenyl-N-tert-butylnitrone (PBN). Biochim Biophys Acta. 1998 Nov 19;1448(1):77-84. [4]. R A Floyd. Antioxidants, Oxidative Stress, and Degenerative Neurological Disorders. Proc Soc Exp Biol Med. 1999 Dec;222(3):236-45.

Density	1.0±0.1 g/cm3
Boiling Point	283.3±23.0 °C at 760 mmHg
Melting Point	71-75ºC
Molecular Formula	C₁₁H₁₅NO
Molecular Weight	177.243
Flash Point	118.5±15.4 °C
Exact Mass	177.115356
PSA	28.75000
LogP	1.25
Appearance of Characters	powder \| white
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.552
Storage condition	2-8°C
Water Solubility	DMSO: soluble

MSDS(Chinese)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xn
Safety Phrases	S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	TX1760000
HS Code	2925290090

Precursor 10
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DownStream 8
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HS Code	2925290090
Summary	2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

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N-tert-Butyl-alpha-phenylnitrone

phenyl t-butyl nitrone

N-Benzylidene-tert-butylamine N-oxide,PBN,Phenyl N-t-butylnitrone

N-tert-Butyl-α-phenylnitrone

Styryl phenyl sulfone

2-Phenylethenyl phenyl sulfone

MFCD00008799

EINECS 222-168-6

N-Benzylidene-N-(2-methyl-2-propanyl)amine oxide

N-benzylidene-tert-butylamine N-oxide

n-tert-butyl-n-[(e)-phenylmethylene]amine oxide

N-benzylidene-t-butylamine N-oxide

PHENYL TRANS-STYRYL SULFONE 99

Azane, (1,1-dimethylethyl)(phenylmethylene)-, oxide

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: n-tert-butyl-n-[(e)-phenylmethylene]amine oxide
Price: ￥490.0/1g ￥1620.0/5g
Purity: 95.0%
Stocking Period: Inquiry
Contact: Liu jia

DC Chemicals Limited
China
Product Name: N-tert-Butyl-α-phenylnitrone
Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: N-tert-butyl-alpha-phenylnitrone
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: N-TERT-BUTYL-ALPHA-PHENYLNITRONE
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

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n-tert-butyl-n-[(e)-phenylmethylene]amine oxide

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