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  • DC Chemicals Limited
  • China
  • Product Name: GW-842166X
  • Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

666260-75-9

666260-75-9 structure
666260-75-9 structure
  • Name: GW842166X
  • Chemical Name: 2-(2,4-dichloroanilino)-N-(oxan-4-ylmethyl)-4-(trifluoromethyl)pyrimidine-5-carboxamide
  • CAS Number: 666260-75-9
  • Molecular Formula: C18H17Cl2F3N4O2
  • Molecular Weight: 449.254
  • Catalog: Biochemical Inhibitor G protein coupled receptor(GPCR & G Protein) Cannabinoid Receptor Agonist
  • Create Date: 2016-09-14 03:17:59
  • Modify Date: 2024-01-14 19:07:17
  • GW842166X is a potent and selective cannabinoid receptor 2 (CB2) agonist with IC50 values of 63 and 91 nM for human and rat CB2, respectively.

Name 2-(2,4-dichloroanilino)-N-(oxan-4-ylmethyl)-4-(trifluoromethyl)pyrimidine-5-carboxamide
Synonyms cc-723
UNII-VL1I6P2DZ8
2-[(2,4-Dichlorophenyl)amino]-N-(tetrahydro-2H-pyran-4-ylmethyl)-4-(trifluoromethyl)-5-pyrimidinecarboxamide
2-((2,4-dichlorphenyl)amino)-N-((tetrahydro-2H-pyran-4-yl)methyl)-4-(trifluoromethyl)-5-pyrimidinecarboxamide
5-Pyrimidinecarboxamide, 2-[(2,4-dichlorophenyl)amino]-N-[(tetrahydro-2H-pyran-4-yl)methyl]-4-(trifluoromethyl)-
GW-842,166X
GW842166X
Description GW842166X is a potent and selective cannabinoid receptor 2 (CB2) agonist with IC50 values of 63 and 91 nM for human and rat CB2, respectively.
Related Catalog
Target

IC50: 63 nM (human CB2), 91 nM (rat CB2)[1]

In Vitro GW842166X shows similar potency and efficacy for rat and human recombinant CB2 receptors. It has no significant agonist activity at concentrations up to 30 µM in human and rat CB1 recombinant assays[1].
In Vivo GW842166X has an oral ED50 of 0.1 mg/kg in the rat FCA model of inflammatory pain and shows full reversal of hyperalgesia at 0.3 mg/kg. The blood concentrations of GW842166X in experiments are 30 nM (0.03 mg/kg), 130 nM (0.1 mg/kg), and 370 nM (0.3 mg/ kg) 1 h after dosing. After dosing for 4 days in the FCA model, no statistical difference in antihyperalgesic response is observed on day 4 relative to day 1, indicating that tolerance does not occur[1].
References

[1]. Giblin GM, et al. Discovery of 2-[(2,4-dichlorophenyl)amino]-N-[(tetrahydro- 2H-pyran-4-yl)methyl]-4-(trifluoromethyl)- 5-pyrimidinecarboxamide, a selective CB2 receptor agonist for the treatment of inflammatory pain. J Med Chem. 2007 May 31;50(11):2597-600.

Density 1.4±0.1 g/cm3
Molecular Formula C18H17Cl2F3N4O2
Molecular Weight 449.254
Exact Mass 448.068054
PSA 79.63000
LogP 3.48
Index of Refraction 1.571
Storage condition -20°C