GW842166X
Modify Date: 2024-01-14 19:07:17
GW842166X structure
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Common Name | GW842166X | ||
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| CAS Number | 666260-75-9 | Molecular Weight | 449.254 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C18H17Cl2F3N4O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of GW842166XGW842166X is a potent and selective cannabinoid receptor 2 (CB2) agonist with IC50 values of 63 and 91 nM for human and rat CB2, respectively. |
| Name | 2-(2,4-dichloroanilino)-N-(oxan-4-ylmethyl)-4-(trifluoromethyl)pyrimidine-5-carboxamide |
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| Synonym | More Synonyms |
| Description | GW842166X is a potent and selective cannabinoid receptor 2 (CB2) agonist with IC50 values of 63 and 91 nM for human and rat CB2, respectively. |
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| Related Catalog | |
| Target |
IC50: 63 nM (human CB2), 91 nM (rat CB2)[1] |
| In Vitro | GW842166X shows similar potency and efficacy for rat and human recombinant CB2 receptors. It has no significant agonist activity at concentrations up to 30 µM in human and rat CB1 recombinant assays[1]. |
| In Vivo | GW842166X has an oral ED50 of 0.1 mg/kg in the rat FCA model of inflammatory pain and shows full reversal of hyperalgesia at 0.3 mg/kg. The blood concentrations of GW842166X in experiments are 30 nM (0.03 mg/kg), 130 nM (0.1 mg/kg), and 370 nM (0.3 mg/ kg) 1 h after dosing. After dosing for 4 days in the FCA model, no statistical difference in antihyperalgesic response is observed on day 4 relative to day 1, indicating that tolerance does not occur[1]. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Molecular Formula | C18H17Cl2F3N4O2 |
| Molecular Weight | 449.254 |
| Exact Mass | 448.068054 |
| PSA | 79.63000 |
| LogP | 3.48 |
| Index of Refraction | 1.571 |
| Storage condition | -20°C |
| cc-723 |
| UNII-VL1I6P2DZ8 |
| 2-[(2,4-Dichlorophenyl)amino]-N-(tetrahydro-2H-pyran-4-ylmethyl)-4-(trifluoromethyl)-5-pyrimidinecarboxamide |
| 2-((2,4-dichlorphenyl)amino)-N-((tetrahydro-2H-pyran-4-yl)methyl)-4-(trifluoromethyl)-5-pyrimidinecarboxamide |
| 5-Pyrimidinecarboxamide, 2-[(2,4-dichlorophenyl)amino]-N-[(tetrahydro-2H-pyran-4-yl)methyl]-4-(trifluoromethyl)- |
| GW-842,166X |
| GW842166X |