87414-49-1

87414-49-1 structure

Name: Butyrolactone I
Chemical Name: [4-hydroxy-3-(3-methylbut-2-enyl)phenyl]methyl (2R)-4-hydroxy-3-(4-hydroxyphenyl)-2-methyl-5-oxofuran-2-carboxylate
CAS Number: 87414-49-1
Molecular Formula: C₂₄H₂₄O₇
Molecular Weight: 424.44300
Create Date: 2017-08-25 11:40:57
Modify Date: 2024-01-04 11:37:47
Butyrolactone I is an ATP-competitive inhibitor of CDK1 as a secondary metabolite from A. terreus[1]. Butyrolactone I has antitumor effects in non-small cell lung, small cell lung, and prostate cancer cell lines[2].

Name	[4-hydroxy-3-(3-methylbut-2-enyl)phenyl]methyl (2R)-4-hydroxy-3-(4-hydroxyphenyl)-2-methyl-5-oxofuran-2-carboxylate

Description	Butyrolactone I is an ATP-competitive inhibitor of CDK1 as a secondary metabolite from A. terreus[1]. Butyrolactone I has antitumor effects in non-small cell lung, small cell lung, and prostate cancer cell lines[2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> CDK
Target	CDK1
References	[1]. Nishio K, et al. Antitumor effects of butyrolactone I, a selective cdc2 kinase inhibitor, on human lung cancer cell lines. Anticancer Res. 1996 Nov-Dec;16(6B):3387-95. P [2]. Suzuki M, et al. Butyrolactone I induces cyclin B1 and causes G2/M arrest and skipping of mitosis in human prostate cell lines. Cancer Lett. 1999 Apr 26;138(1-2):121-30.