778649-18-6
778649-18-6 structure
- Name: Butyrolactone 3
- Chemical Name: (2S,3R)-4-methylidene-5-oxo-2-propyloxolane-3-carboxylic acid
- CAS Number: 778649-18-6
- Molecular Formula: C9H12O4
- Molecular Weight: 184.189
- Catalog: Signaling Pathways Epigenetics Histone Acetyltransferase
- Create Date: 2017-10-02 18:31:19
- Modify Date: 2024-01-03 16:24:23
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Butyrolactone 3 is a specifical small-molecule inhibitor of the histone acetyltransferase Gcn5 (IC50=100 μM), which has a high affinity to the Gcn5 enzyme comparable to that of its natural substrate, histone H3. Butyrolactone 3 shows weak inhibitory on CBP (IC50=0.5 mM)[1]
| Name | (2S,3R)-4-methylidene-5-oxo-2-propyloxolane-3-carboxylic acid |
|---|---|
| Synonyms |
Butyrolactone 3
3-Furancarboxylic acid, tetrahydro-4-methylene-5-oxo-2-propyl-, (2S,3R)- (2S,3R)-4-Methylene-5-oxo-2-propyltetrahydro-3-furancarboxylic acid |
| Description | Butyrolactone 3 is a specifical small-molecule inhibitor of the histone acetyltransferase Gcn5 (IC50=100 μM), which has a high affinity to the Gcn5 enzyme comparable to that of its natural substrate, histone H3. Butyrolactone 3 shows weak inhibitory on CBP (IC50=0.5 mM)[1] |
|---|---|
| Related Catalog | |
| Target |
GCN5:100 μM (IC50) |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 386.2±42.0 °C at 760 mmHg |
| Molecular Formula | C9H12O4 |
| Molecular Weight | 184.189 |
| Flash Point | 158.5±21.4 °C |
| Exact Mass | 184.073563 |
| PSA | 63.60000 |
| LogP | 0.99 |
| Vapour Pressure | 0.0±1.9 mmHg at 25°C |
| Index of Refraction | 1.495 |
| Storage condition | -20°C |