Shanghai Nianxing Industrial Co., Ltd
China
Product Name: BTO-1
Price: Check
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: BTO-1
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

40647-02-7

40647-02-7 structure

40647-02-7 structure

Name: BTO-1
Chemical Name: 5-cyano-7-nitro-3-oxido-1,3-benzothiazol-3-ium-2-carboxamide
CAS Number: 40647-02-7
Molecular Formula: C₉H₄N₄O₄S
Molecular Weight: 264.21700
Catalog: Signaling Pathways Cell Cycle/DNA Damage Polo-like Kinase (PLK)
Create Date: 2017-10-15 17:13:17
Modify Date: 2025-08-21 18:48:18
BTO-1 is a Polo-like kinase (Plk) inhibitor. BTO-1 is primarily used for phosphorylation and dephosphorylation applications[1][2].

Name	5-cyano-7-nitro-3-oxido-1,3-benzothiazol-3-ium-2-carboxamide
Synonyms	BTO-1 5-cyano-7-nitro-3-oxy-benzothiazole-2-carboxylic acid amide HMS3260F21 HMS3229L17 5-Cyano-7-nitro-2-benzothiazolecarboxamide-3-oxide

Description	BTO-1 is a Polo-like kinase (Plk) inhibitor. BTO-1 is primarily used for phosphorylation and dephosphorylation applications[1][2].
Related Catalog	Research Areas >> Others Signaling Pathways >> Cell Cycle/DNA Damage >> Polo-like Kinase (PLK)
Target	Plx1
In Vitro	BTO-1 (50 μM; 4 hours; U20S cells) results in monopolar spindles in a comparable fraction of mitotic cells. BTO-1(20 μM; 1 hour; PTK cells) shows a dose-dependent reduction in phospho-Cdc25C. BTO-1(25 μM; 1 hour; PTK cells) shows about 20 % reduction in H3 phosphorylation compared to control cells. BTO-1 in HeLa cells results in a blockage of Rho and Rho-GEF recruitment, which is essential for the assembly of a functional contractile ring[1][2].
References	[1]. Peters, U., et al. Probing cell-division phenotype space and Polo-like kinase function using small molecules. Nat Chem Biol 2, 618–626 (2006). [2]. Brennan IM, et al. Polo-like kinase controls vertebrate spindle elongation and cytokinesis. PLoS One. 2007;2(5):e409. Published 2007 May 2.

Molecular Formula	C₉H₄N₄O₄S
Molecular Weight	264.21700
Exact Mass	263.99500
PSA	166.40000
LogP	2.43208
Storage condition	2-8°C

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H312-H315-H319-H332-H335
Precautionary Statements	P261-P280-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn
Risk Phrases	20/21/22-36/37/38
Safety Phrases	26-36/37
RIDADR	NONH for all modes of transport

27792-76-3 structure

27792-76-3

~%

40647-02-7 structure

40647-02-7

Literature: Wagner,K. et al. Chemische Berichte, 1973 , vol. 106, p. 640 - 654

Precursor 1
27792-76-3
DownStream 0

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