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40647-02-7

40647-02-7 structure
40647-02-7 structure
  • Name: BTO-1
  • Chemical Name: 5-cyano-7-nitro-3-oxido-1,3-benzothiazol-3-ium-2-carboxamide
  • CAS Number: 40647-02-7
  • Molecular Formula: C9H4N4O4S
  • Molecular Weight: 264.21700
  • Catalog: Signaling Pathways Cell Cycle/DNA Damage Polo-like Kinase (PLK)
  • Create Date: 2017-10-15 17:13:17
  • Modify Date: 2024-01-09 10:11:11
  • BTO-1 is a Polo-like kinase (Plk) inhibitor. BTO-1 is primarily used for phosphorylation and dephosphorylation applications[1][2].
Name 5-cyano-7-nitro-3-oxido-1,3-benzothiazol-3-ium-2-carboxamide
Synonyms BTO-1
5-cyano-7-nitro-3-oxy-benzothiazole-2-carboxylic acid amide
HMS3260F21
HMS3229L17
5-Cyano-7-nitro-2-benzothiazolecarboxamide-3-oxide
Description BTO-1 is a Polo-like kinase (Plk) inhibitor. BTO-1 is primarily used for phosphorylation and dephosphorylation applications[1][2].
Related Catalog
Target

Plx1

In Vitro BTO-1 (50 μM; 4 hours; U20S cells) results in monopolar spindles in a comparable fraction of mitotic cells. BTO-1(20 μM; 1 hour; PTK cells) shows a dose-dependent reduction in phospho-Cdc25C. BTO-1(25 μM; 1 hour; PTK cells) shows about 20 % reduction in H3 phosphorylation compared to control cells. BTO-1 in HeLa cells results in a blockage of Rho and Rho-GEF recruitment, which is essential for the assembly of a functional contractile ring[1][2].
References

[1]. Peters, U., et al. Probing cell-division phenotype space and Polo-like kinase function using small molecules. Nat Chem Biol 2, 618–626 (2006).

[2]. Brennan IM, et al. Polo-like kinase controls vertebrate spindle elongation and cytokinesis. PLoS One. 2007;2(5):e409. Published 2007 May 2.
Molecular Formula C9H4N4O4S
Molecular Weight 264.21700
Exact Mass 263.99500
PSA 166.40000
LogP 2.43208
Storage condition 2-8°C
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302-H312-H315-H319-H332-H335
Precautionary Statements P261-P280-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xn
Risk Phrases 20/21/22-36/37/38
Safety Phrases 26-36/37
RIDADR NONH for all modes of transport
Precursor  1

DownStream  0


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title: CAS No. 40647-02-7 | Chemsrc address: https://www.chemsrc.com/en/baike/374791.html

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