103884-98-6

103884-98-6 structure

Name: 2'-Deoxy-2'-fluoroguanosine
Chemical Name: 2-amino-9-[(3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one
CAS Number: 103884-98-6
Molecular Formula: C₁₀H₁₂FN₅O₄
Molecular Weight: 285.23
Catalog: Signaling Pathways Cell Cycle/DNA Damage Nucleoside Antimetabolite/Analog
Create Date: 2018-09-05 18:17:57
Modify Date: 2025-08-25 18:35:12
2-Amino-9-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3,9-dihydro-6H-purin-6-one (9-β-D-[2'-Fluoro-2'-deoxy-arabinofuranosyl]-guanin) is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

Name	2-amino-9-[(3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one
Synonyms	6H-Purin-6-one, 2-amino-9-(2-deoxy-2-fluoro-D-arabinofuranosyl)-1,9-dihydro- 2-Amino-9-(2-deoxy-2-fluoro-D-arabinofuranosyl)-1,9-dihydro-6H-purin-6-one 2'-Deoxy-2'-fluoroguanosine Guanosine, 2'-deoxy-2'-fluoro-

Description	2-Amino-9-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3,9-dihydro-6H-purin-6-one (9-β-D-[2'-Fluoro-2'-deoxy-arabinofuranosyl]-guanin) is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog Research Areas >> Others
References	[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

CHEMICAL NAME :: 6H-Purin-6-one, 2-amino-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)- 1,9-dihydro-

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 29,2389,1986