103884-98-6

• 常用中文名：9-(2-脱氧-2-氟阿拉伯呋喃基)鸟嘌呤
• 常用英文名：2'-Deoxy-2'-fluoroguanosine
• CAS号：103884-98-6
• 分子式：C₁₀H₁₂FN₅O₄
• 分子量：285.23
• 相关类别： 信号通路 细胞周期/DNA损伤 核苷抗代谢药/类似物
• 发布时间：2018-09-05 18:17:57
• 更新时间：2026-07-07 09:25:08
• 2-氨基-9-((2R,3S,4R,5R)-3-氟-4-羟基-5-(羟甲基)四氢呋喃-2-基)-3,9-二氢-6H-嘌呤-6-酮(9-β-D-[2'-氟-2'-脱氧阿拉伯呋喃基]-鸟嘌呤)是嘌呤核苷类似物。嘌呤核苷类似物具有广泛的抗肿瘤活性,靶向惰性淋巴系统恶性肿瘤。这一过程中的抗癌机制依赖于抑制DNA合成、诱导细胞凋亡等[1]。

名称

• 中文名: 9-(2-脱氧-2-氟阿拉伯呋喃基)鸟嘌呤
• 英文名: 2-amino-9-[(3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one
• 中文别名: 9-(2-脱氧-2-氟-BETA-D-阿拉伯呋喃基)鸟嘌呤; 2'-脱氧-2'-氟-阿糖鸟苷; 2-氨基-9-((2R,3S,4R,5R)-3-氟-4-羟基-5-(羟甲基)四氢呋喃-2-基)-1H-嘌呤-6(9H)-酮; 2'-脱氧-2'-氟阿拉伯鸟苷
• 英文别名: 2''-Deoxy-2''-fluoro-beta-D-abinoguanosine; 2-Amino-9-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1H-purin-6(9H)-one; 2'-Deoxy-2'-fluoro-beta-D-abinoguanosine; 2'-Fluoro-2'-deoxy-abinofuranosyl-guanosine; 2’-Deoxy-2’-fluoro-beta-D-abinoguanosine, 9-(2-Deoxy-2-fluoro-beta-D-abinofuranosyl) guanine; a-2'-F-2'-dG; 2-Amino-9-(2-deoxy-2-fluoro-D-arabinofuranosyl)-1,9-dihydro-6H-purin-6-one; 2'-FANA-guanosine; 2’-Deoxy-2’-fluoro-b-D-abinoguanosine; 9-(2-deoxy-2-fluoroabinofuranosyl)guanine; 9-β-D-[2'-Fluoro-2'-deoxy-abinofuranosyl]-guanine; 9-(2'-Deoxy-2'-fluoro-b-D-abinofuranosyl)guanine; 9-(2-deoxy-2-fluoro-β-D-abinofuranosyl)guanine; 2’-Deoxy-2’-fluoro-b-D-abinoguanosine Anticancer agent, clofabine’s impurity C; 2’-Deoxy-2’-fluoro-β-D-abinoguanosine; 2'-Fluoro-2'-deoxy-abino-Guanosine; 9-(2-Deoxy-2-fluoro-beta-D-abinofuranosyl)guanine; 9-B-D-[2-FLUORO-2-DEOXY-ABINOFURANSYL]- GUANINE; 9-β-D-[2'-Fluoro-2'-deoxy-abinofuranosyl]-guanin; 2-Amino-9-[(3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one; 6H-Purin-6-one, 2-amino-9-(2-deoxy-2-fluoro-β-D-abinofuranosyl)-1,9-dihydro; 2’-Deoxy-2’-fluoro-beta-D-abinoguanosine

物化性质

• 密度: 2.2±0.1 g/cm3
• 沸点: 726.1ºC
• 分子式: C₁₀H₁₂FN₅O₄
• 分子量: 285.23
• 闪点: 392.9ºC
• 精确质量: 285.087341
• PSA: 139.28000
• LogP: -0.53
• 蒸汽压: 3.94E-22mmHg at 25°C
• 折射率: 1.876
• 储存条件: 2-8℃，避光

生物活性

• 描述: 2-氨基-9-((2R,3S,4R,5R)-3-氟-4-羟基-5-(羟甲基)四氢呋喃-2-基)-3,9-二氢-6H-嘌呤-6-酮(9-β-D-[2'-氟-2'-脱氧阿拉伯呋喃基]-鸟嘌呤)是嘌呤核苷类似物。嘌呤核苷类似物具有广泛的抗肿瘤活性,靶向惰性淋巴系统恶性肿瘤。这一过程中的抗癌机制依赖于抑制DNA合成、诱导细胞凋亡等[1]。
• 相关类别:
  信号通路 >> 细胞周期/DNA损伤 >> 核苷抗代谢药/类似物
  研究领域 >> 其他
• 参考文献:

  [1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : UP0789000 CHEMICAL NAME : 6H-Purin-6-one, 2-amino-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)- 1,9-dihydro- CAS REGISTRY NUMBER : 103884-98-6 LAST UPDATED : 199612 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C10-H12-F-N5-O4 MOLECULAR WEIGHT : 285.27 HEALTH HAZARD DATA ACUTE TOXICITY DATA MUTATION DATA TYPE OF TEST : DNA inhibition TEST SYSTEM : Rodent - mouse Leukocyte DOSE/DURATION : 50 umol/L REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 29,2389,1986

合成路线

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