2'-Deoxy-2'-fluoroguanosine

Modify Date: 2025-08-25 18:35:12

2'-Deoxy-2'-fluoroguanosine structure	Common Name	2'-Deoxy-2'-fluoroguanosine
	CAS Number	103884-98-6	Molecular Weight	285.23
	Density	2.2±0.1 g/cm3	Boiling Point	726.1ºC
	Molecular Formula	C₁₀H₁₂FN₅O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	392.9ºC

Use of 2'-Deoxy-2'-fluoroguanosine

2-Amino-9-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3,9-dihydro-6H-purin-6-one (9-β-D-[2'-Fluoro-2'-deoxy-arabinofuranosyl]-guanin) is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

Name	2-amino-9-[(3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one
Synonym	More Synonyms

Description	2-Amino-9-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3,9-dihydro-6H-purin-6-one (9-β-D-[2'-Fluoro-2'-deoxy-arabinofuranosyl]-guanin) is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog Research Areas >> Others
References	[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Density	2.2±0.1 g/cm3
Boiling Point	726.1ºC
Molecular Formula	C₁₀H₁₂FN₅O₄
Molecular Weight	285.23
Flash Point	392.9ºC
Exact Mass	285.087341
PSA	139.28000
LogP	-0.53
Vapour Pressure	3.94E-22mmHg at 25°C
Index of Refraction	1.876

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UP0789000

CHEMICAL NAME :: 6H-Purin-6-one, 2-amino-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)- 1,9-dihydro-

CAS REGISTRY NUMBER :: 103884-98-6

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C10-H12-F-N5-O4

MOLECULAR WEIGHT :: 285.27

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Rodent - mouse Leukocyte

DOSE/DURATION :: 50 umol/L

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 29,2389,1986

Precursor 9
CAS#:118373-61-8 2-Amino-6-chlor... CAS#:5451-40-1 2,6-Dichloropurine CAS#:56632-81-6 1,3-di-O-acetyl... CAS#:103884-99-7 9H-Purine, 9-(3...
CAS#:103885-01-4 2,6-diazido-9-(... CAS#:109303-94-8 9-(3-O-acetyl-5... CAS#:97614-44-3 2-Deoxy-2-fluor... CAS#:72101-44-1 6-Chloro-9,N-bi...
CAS#:103885-02-5 9-(3-O-acetyl-5...
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