Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Minaprine (dihydrochloride)
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 4-Morpholineethanamine,N-(4-methyl-6-phenyl-3-pyridazinyl)-, hydrochloride (1:2)
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Purity: 98.0%
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25953-17-7

25953-17-7 structure

25953-17-7 structure

Name: Minaprine (dihydrochloride)
Chemical Name: minaprine hydrochloride
CAS Number: 25953-17-7
Molecular Formula: C₁₇H₂₄Cl₂N₄O
Molecular Weight: 371.30
Catalog: Signaling Pathways Neuronal Signaling Monoamine Oxidase
Create Date: 2018-12-26 08:12:59
Modify Date: 2025-08-27 11:42:43
Minaprine 2Hcl is a reversible inhibitor of MAO-A; weakly inhibit acetylcholinesterase; an antidepressant for treatment of depression.

Name	minaprine hydrochloride
Synonyms	Ag 620 Agr 620 Pyridazine, 4-methyl-3-[(2-morpholinoethyl)amino]-6-phenyl-, dihydrochloride Agr 1240 4-Morpholineethanamine,N-(4-methyl-6-phenyl-3-pyridazinyl)-,dihydrochloride Morpholine,4-[2-[(4-methyl-6-phenyl-3-pyridazinyl)amino]ethyl]-,dihydrochloride Minaprine (dihydrochloride)

Description	Minaprine 2Hcl is a reversible inhibitor of MAO-A; weakly inhibit acetylcholinesterase; an antidepressant for treatment of depression.
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase Research Areas >> Neurological Disease
References	[1]. Kan JP, et al. Effect of the antidepressant minaprine on both forms of monoamine oxidase in the rat. Biochem Pharmacol. 1986 Mar 15;35(6):973-8. [2]. Contreras JM, et al. Aminopyridazines as acetylcholinesterase inhibitors. J Med Chem. 1999 Feb 25;42(4):730-41.

Boiling Point	531.2ºC at 760 mmHg
Molecular Formula	C₁₇H₂₄Cl₂N₄O
Molecular Weight	371.30
Flash Point	275.1ºC
PSA	50.28000
LogP	3.00900
Vapour Pressure	2.29E-11mmHg at 25°C
Storage condition	2-8℃

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QE3477835

CHEMICAL NAME :: 4-Morpholineethanamine, N-(4-methyl-6-phenyl-3-pyridazinyl)-, dihydrochloride

CAS REGISTRY NUMBER :: 25953-17-7

LAST UPDATED :: 199707

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C17-H22-N4-O.2Cl-H

MOLECULAR WEIGHT :: 371.35

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >100 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 32,824,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 63 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4508720 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4823 mg/kg/13W-I

TOXIC EFFECTS :: Endocrine - changes in adrenal weight Endocrine - changes in thymus weight

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 24,1894,1990

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