25953-17-7

• 常用中文名：Minaprine dihydrochloride
• 常用英文名：Minaprine (dihydrochloride)
• CAS号：25953-17-7
• 分子式：C₁₇H₂₄Cl₂N₄O
• 分子量：371.30
• 相关类别： 信号通路 神经信号通路 单胺氧化酶
• 发布时间：2018-12-26 08:12:59
• 更新时间：2025-08-27 11:42:43
• Minaprine二盐酸盐是单胺氧化酶MAO-A可逆性抑制剂,还对乙酰胆碱酯酶有微弱抑制,抗抑郁类化合物。

名称

• 中文名: 4-甲基-N-(2-吗啉-4-乙基)-6-苯基吡嗪-3-胺
• 英文名: minaprine hydrochloride
• 英文别名: Ag 620; Agr 620; Pyridazine, 4-methyl-3-[(2-morpholinoethyl)amino]-6-phenyl-, dihydrochloride; Agr 1240; 4-Morpholineethanamine,N-(4-methyl-6-phenyl-3-pyridazinyl)-,dihydrochloride; Morpholine,4-[2-[(4-methyl-6-phenyl-3-pyridazinyl)amino]ethyl]-,dihydrochloride; Minaprine (dihydrochloride)

物化性质

• 沸点: 531.2ºC at 760 mmHg
• 分子式: C₁₇H₂₄Cl₂N₄O
• 分子量: 371.30
• 闪点: 275.1ºC
• PSA: 50.28000
• LogP: 3.00900
• 蒸汽压: 2.29E-11mmHg at 25°C
• 储存条件: 2-8℃

生物活性

• 描述: Minaprine二盐酸盐是单胺氧化酶MAO-A可逆性抑制剂,还对乙酰胆碱酯酶有微弱抑制,抗抑郁类化合物。
• 相关类别:
  信号通路 >> 神经信号通路 >> 单胺氧化酶
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Kan JP, et al. Effect of the antidepressant minaprine on both forms of monoamine oxidase in the rat. Biochem Pharmacol. 1986 Mar 15;35(6):973-8.

  [2]. Contreras JM, et al. Aminopyridazines as acetylcholinesterase inhibitors. J Med Chem. 1999 Feb 25;42(4):730-41.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : QE3477835 CHEMICAL NAME : 4-Morpholineethanamine, N-(4-methyl-6-phenyl-3-pyridazinyl)-, dihydrochloride CAS REGISTRY NUMBER : 25953-17-7 LAST UPDATED : 199707 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C17-H22-N4-O.2Cl-H MOLECULAR WEIGHT : 371.35 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >100 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 32,824,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 63 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4508720 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 4823 mg/kg/13W-I TOXIC EFFECTS : Endocrine - changes in adrenal weight Endocrine - changes in thymus weight REFERENCE : KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 24,1894,1990