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49557-75-7

49557-75-7 structure
49557-75-7 structure
  • Name: Copper Peptide
  • Chemical Name: Gly-His-Lys
  • CAS Number: 49557-75-7
  • Molecular Formula: C14H24N6O4
  • Molecular Weight: 340.378
  • Catalog: Biochemical Amino acids and their derivatives Lysine derivative
  • Create Date: 2018-09-23 02:08:58
  • Modify Date: 2025-08-23 14:51:49
  • Glycyl-L-histidyl-L-lysine is a tripeptide consisting of glycine, L-histidine and L-lysine residues joined in sequence. Glycyl-L-histidyl-L-lysine is a hepatotropic immunosuppressor and shows anxiolytic effect. Glycyl-L-histidyl-L-lysine and its copper complexes show good skin tolerance[1][2][3].
Name Gly-His-Lys
Synonyms Liver growth factor
Gly-L-His-L-Lys
Liver cell growth factor
L-Lysine, glycyl-L-histidyl-
Glycyl-L-Histidyl-L-Lysine
GHK Cu Copper Peptide
H-Gly-His-Lys-OH
glycyl-histidyl-lysine
ghk
Copper Peptide
Ahk-cu
Growth-modulating peptide
Gly-His-Lys-Cu
Copper Peptide (GHK-Cu)
Description Glycyl-L-histidyl-L-lysine is a tripeptide consisting of glycine, L-histidine and L-lysine residues joined in sequence. Glycyl-L-histidyl-L-lysine is a hepatotropic immunosuppressor and shows anxiolytic effect. Glycyl-L-histidyl-L-lysine and its copper complexes show good skin tolerance[1][2][3].
Related Catalog
In Vitro Glycyl-L-histidyl-L-lysine and its copper complexes and saccharomyces/copper ferment on secretion of pro-inflammatory IL-6 in normal human dermal fibroblasts NHDF cell line[1]. Glycyl-L-histidyl-L-lysine and its copper complexes decreases TNF-α-dependent IL-6 secretion in fibroblasts[1].
In Vivo Glycyl-L-histidyl-L-lysine (intraperitoneal injection; 1.5, 5, 50, 150, and 450 mg/kg; 10 times ) can stimulate mitotic activity of hepatocytes and dose-dependently suppresse immune reactivity[2]. Glycyl-L-histidyl-L-lysine (intraperitoneal injection; 0.5, 5, and 50 μg/kg) can produce an anxiolytic effect in the elevated plus maze test[3].
References

[1]. Arkadiusz Gruchlik, et al. Effect of Gly-Gly-His, Gly-His-Lys and their copper complexes on TNF-alpha-dependent IL-6 secretion in normal human dermal fibroblasts. Acta Pol Pharm. 2012 Nov-Dec;69(6):1303-6.

[2]. M Yu Smakhtin, et al. Tripeptide Gly-His-Lys is a hepatotropic immunosuppressor. Bull Exp Biol Med. 2002 Jun;133(6):586-7.

[3]. I Bobyntsev, et al. Anxiolytic effects of Gly-His-Lys peptide and its analogs. Bull Exp Biol Med. 2015 Apr;158(6):726-8.
Density 1.3±0.1 g/cm3
Boiling Point 831.0±65.0 °C at 760 mmHg
Molecular Formula C14H24N6O4
Molecular Weight 340.378
Flash Point 456.4±34.3 °C
Exact Mass 340.185913
PSA 176.22000
LogP -2.24
Vapour Pressure 0.0±3.2 mmHg at 25°C
Index of Refraction 1.583
Storage condition 2-8°C
Hazard Codes Xi
HS Code 2933290090
Precursor  3

DownStream  0

HS Code 2933290090
Summary 2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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