- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: 17-HYDROXY-6-METHYL-19-NORPREGNA-4,6-DIENE-3,20-DIONE
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Ms Wang
- Zhejiang Hangyu API Co., Ltd
- China
- Product Name: Nomegestrol
- Price: ￥Inquiry/1kg
- Purity: 99.5%
- Stocking Period: Inquiry
- Contact: Vinnie
- Henan Tianfu Chemical Co., Ltd.
- China
- Product Name: Nomegestrol
- Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
- Purity: 99.0%
- Stocking Period: Inquiry
- Contact: Anson
58691-88-6
58691-88-6 structure
- Name: Nomegestrol
- Chemical Name: 17-Hydroxy-6-methyl-19-norpregna-4,6-diene-3,20-dione
- CAS Number: 58691-88-6
- Molecular Formula: C21H28O3
- Molecular Weight: 328.45
- Catalog: API Hormone and endocrine-regulating drugs Estrogen and progestogen drugs
- Create Date: 2018-05-21 08:00:00
- Modify Date: 2024-01-06 11:05:21
-
Nomegestrol is a potent and orally available progestin, acts as a selective full progesterone receptor agonist, with a Kd of 5.44 nM for rat uterine progesterone receptor, and has moderate antiandrogenic activity and strong antiestrogenic activity.
| Name | 17-Hydroxy-6-methyl-19-norpregna-4,6-diene-3,20-dione |
|---|---|
| Synonyms |
Nomegestrol
(17a)-17-Acetyl-17-hydroxy-6-methylestra-4,6-dien-3-one 19-Norpregna-4,6-diene-3,20-dione, 17-hydroxy-6-methyl- Estra-4,6-dien-3-one, 17-acetyl-17-hydroxy-6-methyl-, (17α)- 17-Hydroxy-6-methyl-19-norpregna-4,6-diene-3,20-dione |
| Description | Nomegestrol is a potent and orally available progestin, acts as a selective full progesterone receptor agonist, with a Kd of 5.44 nM for rat uterine progesterone receptor, and has moderate antiandrogenic activity and strong antiestrogenic activity. |
|---|---|
| Related Catalog | |
| Target |
Kd: 5.44 nM (Rat uterine progesterone receptor)[1] |
| In Vitro | Nomegestrol is a progestin, has high binding affinity at progesterone receptor, with a Kd of 5.44 nM for rat uterine progesterone receptor[1]. Nomegestrol acetate (NOMAC) is a higly selective progesterone receptor full agonist, but shows no or little binding affinity at other steroid receptors, such as the androgen and glucocorticoid receptors. Nomegestrol acetate has moderate antiandrogenic activity and strong antiestrogenic activity[2]. |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 502.6±50.0 °C at 760 mmHg |
| Melting Point | 204-205ºC |
| Molecular Formula | C21H28O3 |
| Molecular Weight | 328.45 |
| Flash Point | 271.8±26.6 °C |
| Exact Mass | 328.203857 |
| PSA | 54.37000 |
| LogP | 2.58 |
| Vapour Pressure | 0.0±2.9 mmHg at 25°C |
| Index of Refraction | 1.574 |
| Storage condition | 2~8°C |
| Risk Phrases | 63-50 |
|---|---|
| WGK Germany | 3.0 |